Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng From Burkina Faso, and Effects Against Prostate and Cervical Cancer Cell Lines

Bagora Bayala
* ,
Laetizia Liz Coulibaly
,
Florencia Djigma
ORCID logo ,
Julio Bunay
,
Albert Yonli
,
Lassina Traore
,
Silvère Baron
,
Gilles Figueredo
,
Jacques Simpore
ORCID logo ,
Jean-Marc A. Lobaccaro
* ORCID logo
Version 1 : Received: 2 May 2023 / Approved: 3 May 2023 / Online: 3 May 2023 (09:21:43 CEST)

A peer-reviewed article of this Preprint also exists.

Bayala, B.; Coulibaly, L.L.; Djigma, F.; Bunay, J.; Yonli, A.; Traore, L.; Baron, S.; Figueredo, G.; Simpore, J.; Lobaccaro, J.-M.A. Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng from Burkina Faso, and Effects against Prostate and Cervical Cancer Cell Lines. Molecules 2023, 28, 4561. Bayala, B.; Coulibaly, L.L.; Djigma, F.; Bunay, J.; Yonli, A.; Traore, L.; Baron, S.; Figueredo, G.; Simpore, J.; Lobaccaro, J.-M.A. Chemical Composition of Essential Oil of Cymbopogon schoenanthus (L.) Spreng from Burkina Faso, and Effects against Prostate and Cervical Cancer Cell Lines. Molecules 2023, 28, 4561.

Abstract

The aim of this research was to evaluate the essential oil of Cymbopogon schoenanthus (L.) Spreng. (C. schoenanthus) from Burkina Faso in cytotoxic activity against LNCaP cells, derived from prostate cancer, and HeLa cells, derived from cervical cancer. Antioxidant activities were evaluated in vitro. Essential oil (EO) was extracted by hydrodistillation and analyzed by GC / FID and GC / MS. Thirty-seven compounds were identified, the major compounds being piperitone (49.9%), alpha terpinene isomer (24.02%), elemol (5.79%) and limonene (4.31%). EO exhibited a poor antioxidant activity, as shown by the inhibition of DPPH radicals (IC50 =1730 ± 80 µg/mL) and ABTS+. (IC50 = 2890 ± 26.9 µg/mL). Conversely, EO decreased the proliferation of LNCaP and HeLa cells with respective IC50s of 135.53 ± 5.27 µg/mL and 146.17 ± 11 µg/mL. EO also prevented LNCaP cell migration and led to the arrest of their cell cycle in the G2/M phase. Altogether, this work points out for the first time that EO of C. schoenanthus from Burkina Faso could be an effective natural anticancer agent.

Keywords

Cymbopogon schoenanthus; essential oil; antioxidant; cytotoxic; antimigratory; cell cycle; cancer

Subject

Medicine and Pharmacology, Pharmacology and Toxicology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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