Salameh, L.; Mahmood, W.; Hamoudi, R.; Almazrouei, K.; Lochanan, M.; Seyhoglu, S.; Mahboub, B. The Role of Vitamin D Supplementation on Airway Remodeling in Asthma: A Systematic Review. Nutrients2023, 15, 2477.
Salameh, L.; Mahmood, W.; Hamoudi, R.; Almazrouei, K.; Lochanan, M.; Seyhoglu, S.; Mahboub, B. The Role of Vitamin D Supplementation on Airway Remodeling in Asthma: A Systematic Review. Nutrients 2023, 15, 2477.
Salameh, L.; Mahmood, W.; Hamoudi, R.; Almazrouei, K.; Lochanan, M.; Seyhoglu, S.; Mahboub, B. The Role of Vitamin D Supplementation on Airway Remodeling in Asthma: A Systematic Review. Nutrients2023, 15, 2477.
Salameh, L.; Mahmood, W.; Hamoudi, R.; Almazrouei, K.; Lochanan, M.; Seyhoglu, S.; Mahboub, B. The Role of Vitamin D Supplementation on Airway Remodeling in Asthma: A Systematic Review. Nutrients 2023, 15, 2477.
Abstract
Asthma is a common chronic respiratory disease that affects millions of people worldwide, and its prevalence continues to increase. Vitamin D has been proposed as a potential environmental factor in asthma pathogenesis, due to its immunomodulatory effects. This systematic review aimed to evaluate the effect of vitamin D supplementation on airway remodeling in asthma. We conducted a comprehensive search of electronic databases and identified experimental studies and randomized controlled trials that investigated the impact of vitamin D supplementation on airway remodeling in asthma. The studies included in this review suggest that vitamin D inhibits airway smooth muscle cell contraction and remodeling, reduces inflammation, and regulates collagen synthesis in the airways, and modulates the action of bronchial fibroblasts. However, one study suggests that TGF-β1 can impair vitamin D-induced and constitutive airway epithelial host defense mechanisms. Overall, vitamin D appears to influence many of the pathways central to asthma progression, indicating a promising potential in asthma management and prevenation of asthma progression.
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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