Seymour, E.; Ekiz Kanik, F.; Diken Gür, S.; Bakhshpour-Yucel, M.; Araz, A.; Lortlar Ünlü, N.; Ünlü, M.S. Solid-Phase Optical Sensing Techniques for Sensitive Virus Detection. Sensors 2023, 23, 5018. https://doi.org/10.3390/s23115018
Seymour, E.; Ekiz Kanik, F.; Diken Gür, S.; Bakhshpour-Yucel, M.; Araz, A.; Lortlar Ünlü, N.; Ünlü, M.S. Solid-Phase Optical Sensing Techniques for Sensitive Virus Detection. Sensors 2023, 23, 5018. https://doi.org/10.3390/s23115018
Seymour, E.; Ekiz Kanik, F.; Diken Gür, S.; Bakhshpour-Yucel, M.; Araz, A.; Lortlar Ünlü, N.; Ünlü, M.S. Solid-Phase Optical Sensing Techniques for Sensitive Virus Detection. Sensors 2023, 23, 5018. https://doi.org/10.3390/s23115018
Seymour, E.; Ekiz Kanik, F.; Diken Gür, S.; Bakhshpour-Yucel, M.; Araz, A.; Lortlar Ünlü, N.; Ünlü, M.S. Solid-Phase Optical Sensing Techniques for Sensitive Virus Detection. Sensors 2023, 23, 5018. https://doi.org/10.3390/s23115018
Abstract
Viral infections can endanger public health by causing serious illness, leading to pandemics and burdening healthcare systems. Moreover, in the situation of a global spread, disruptions occur in every aspect of life including business, education, and social life. Fast and accurate diagnosis of viral infections has huge implications for saving people’s lives, preventing spread of the diseases, and minimizing social and economic damages. In the last decades, polymerase chain reaction (PCR) based techniques have been frequently used to detect viruses in the clinic. However, in a situation where rapid virus detection is the primary measure in preventing the spread, as in the case of ongoing COVID-19 pandemic, disadvantages of PCR, such as long processing times and requirement of sophisticated laboratory instruments, have been faced. Due to the urgent need for accurate techniques for virus detection, biosensor systems involved in many applications in biological detection are being developed for rapid, real-time, and high-throughput detection of viruses. Among various sensing platforms, optical devices are of great interest due to their advantages such as high sensitivity and direct readout. In the current review, usability of sensing techniques depending on optical phenomena, such as fluorescence-based sensors, surface plasmon resonance (SPR), surface enhanced Raman scattering (SERS), optical resonators and interferometry-based platforms, is discussed for virus diagnostics applications. Then, we focus on an interferometric biosensor developed by our group, single-particle interferometric reflectance imaging sensor (SP-IRIS), which has the capability to visualize single nanoparticles, to demonstrate its application for digital virus detection.
Engineering, Electrical and Electronic Engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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