Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Pulmonary Recruitment Prior to One-Stage Multiple Pulmonary Ground Glass Nodule Localization Increases Localization Accuracy

Yu Hsiang Wang
† ORCID logo ,
Pei Chin Su
† ,
Kenneth Au
,
Hsu Chih Huang
,
Frank Cheau-Feng Lin
ORCID logo ,
Chih-Yi Chen
,
Ming Chih Chou
,
Jiun Yi Hsia
*
†
These authors contributed equally to the work.
Version 1 : Received: 9 April 2023 / Approved: 10 April 2023 / Online: 10 April 2023 (09:30:44 CEST)

A peer-reviewed article of this Preprint also exists.

Wang, Y.H.; Su, P.C.; Huang, H.C.; Au, K.; Lin, F.C.F.; Chen, C.Y.; Chou, M.C.; Hsia, J.Y. Pulmonary Recruitment Prior to Intraoperative Multiple Pulmonary Ground-Glass Nodule Localization Increases the Localization Accuracy—A Retrospective Study. J. Clin. Med. 2023, 12, 2998. Wang, Y.H.; Su, P.C.; Huang, H.C.; Au, K.; Lin, F.C.F.; Chen, C.Y.; Chou, M.C.; Hsia, J.Y. Pulmonary Recruitment Prior to Intraoperative Multiple Pulmonary Ground-Glass Nodule Localization Increases the Localization Accuracy—A Retrospective Study. J. Clin. Med. 2023, 12, 2998.

Abstract

The standard treatment for early-stage lung cancer is complete tumor excision by limited resection of the lung. Pre-operative localization is used before video-assisted thoracoscopic surgery (VATS) to improve the accuracy of pulmonary nodule excision. However, lung atelectasis and hypoxia resulting from controlling apnea during the localization procedure may affect the localization accuracy. Pre-procedural pulmonary recruitment may improve respiratory mechanics and oxygenation during localization. In this study, we investigated the potential benefits of pre-localization pulmonary recruitment prior to pulmonary ground-glass nodule localization in a hybrid operating room. We hypothesized that pre-localization pulmonary recruitment would increase localization accuracy, improve oxygenation, and prevent the need for re-inflation during the localization procedure. We retrospectively enrolled patients with multiple pulmonary nodule localizations before surgical intervention in our hybrid operating room. We compared localization accuracies between patients who had undergone pre-procedure pulmonary recruitment and patients who had not. Saturation, re-inflation rate, apnea time, procedure-related pneumothorax, and procedure time were also recorded as secondary outcomes. Patients who had undergone pre-procedure recruitment had better saturation, shorter procedure time, and higher localization accuracy. The pre-procedure pulmonary recruitment maneuver was effective in increasing regional lung ventilation, leading to improved oxygenation and localization accuracy.

Keywords

Hybrid computer tomography; pulmonary ground glass nodule localization; video-assisted thoracic surgery; pulmonary recruitment

Subject

Medicine and Pharmacology, Pulmonary and Respiratory Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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