Mohseni Afshar, Z.; Nazari Rostami, H.; Tavakoli Pirzaman, A.; Hosseinzadeh, R.; Babazadeh, A.; Hosseinzadeh, D.; Miri, S.R.; Sio, T.T.; Barary, M.; Ebrahimpour, S. Capillary Leak Syndrome after SARS-CoV-2 Infection and COVID-19 Vaccines: A Comparative Review. Preprints2023, 2023010195. https://doi.org/10.20944/preprints202301.0195.v1
APA Style
Mohseni Afshar, Z., Nazari Rostami, H., Tavakoli Pirzaman, A., Hosseinzadeh, R., Babazadeh, A., Hosseinzadeh, D., Miri, S.R., Sio, T.T., Barary, M., & Ebrahimpour, S. (2023). Capillary Leak Syndrome after SARS-CoV-2 Infection and COVID-19 Vaccines: A Comparative Review. Preprints. https://doi.org/10.20944/preprints202301.0195.v1
Chicago/Turabian Style
Mohseni Afshar, Z., Mohammad Barary and Soheil Ebrahimpour. 2023 "Capillary Leak Syndrome after SARS-CoV-2 Infection and COVID-19 Vaccines: A Comparative Review" Preprints. https://doi.org/10.20944/preprints202301.0195.v1
Abstract
Systemic capillary leak syndrome (SCLS) is an uncommon, potentially life-threatening disorder defined as recurrent attacks of pseudo-shock. This syndrome occurs due to the disruption of endothelial cells, which leads to increased vascular permeability, causing intravascular fluid to leak into the extravascular space and albumin to be retained in the interstitial space. SCLS can lead to hypovolemia, peripheral hypoperfusion, and acute renal insufficiency. The syndrome is presented with fever, generalized edema, pleural effusions, dyspnea, hypovolemia, hemoconcentration, prerenal azotemia, shock, and syncope. After ruling out other causes of hypovolemic shock, the diagnosis of SCLS can be considered on the presence of the classical triad of hypotension, hemoconcentration, and hypoalbuminemia. Eliminating the precipitating factors is the cornerstone of SCLS management. It is advisable to be very cautious and weigh the risks and benefits of vaccination of people with a history of this condition. This review will discuss and compare different aspects of SLCS after SARS-CoV-2 infection and COVID-19 vaccination.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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