PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
New Insights into the (A)Synchronicity of Diels-Alder Reactions: A Theoretical Study Based on the Reaction Force Analysis and Atomic Resolution of Energy Derivatives
Version 1
: Received: 11 January 2022 / Approved: 14 January 2022 / Online: 14 January 2022 (16:53:36 CET)
How to cite:
Isamura, B.K.; Lobb, K.A. New Insights into the (A)Synchronicity of Diels-Alder Reactions: A Theoretical Study Based on the Reaction Force Analysis and Atomic Resolution of Energy Derivatives. Preprints2022, 2022010219. https://doi.org/10.20944/preprints202201.0219.v1
Isamura, B.K.; Lobb, K.A. New Insights into the (A)Synchronicity of Diels-Alder Reactions: A Theoretical Study Based on the Reaction Force Analysis and Atomic Resolution of Energy Derivatives. Preprints 2022, 2022010219. https://doi.org/10.20944/preprints202201.0219.v1
Isamura, B.K.; Lobb, K.A. New Insights into the (A)Synchronicity of Diels-Alder Reactions: A Theoretical Study Based on the Reaction Force Analysis and Atomic Resolution of Energy Derivatives. Preprints2022, 2022010219. https://doi.org/10.20944/preprints202201.0219.v1
APA Style
Isamura, B.K., & Lobb, K.A. (2022). New Insights into the (A)Synchronicity of Diels-Alder Reactions: A Theoretical Study Based on the Reaction Force Analysis and Atomic Resolution of Energy Derivatives. Preprints. https://doi.org/10.20944/preprints202201.0219.v1
Chicago/Turabian Style
Isamura, B.K. and Kevin Alan Lobb. 2022 "New Insights into the (A)Synchronicity of Diels-Alder Reactions: A Theoretical Study Based on the Reaction Force Analysis and Atomic Resolution of Energy Derivatives" Preprints. https://doi.org/10.20944/preprints202201.0219.v1
Abstract
In the present manuscript, we report new insights into the concept of (a)synchronicity in Diels-Alder (DA) reactions in the framework of the reaction force analysis, in conjunction with natural population calculations and atomic resolution of energy derivatives along the intrinsic reaction coordinate (IRC) path. Our findings suggest that the DA reaction transitions between a preferentially concerted mechanism to a stepwise one in a 0.10 Å window of synchronicity indices, ranging from 0.90 to 1.00 Å. We have also shown that the relative position of the global minimum of the reaction force constant with respect to the TS is an alternative and quantifiable indicator of the (a)synchronicity in DA reactions. Moreover, the atomic resolution of energy derivatives reveals that the mechanism of the DA reaction involves two inner elementary processes associated with the formation of each of the two C-C bonds. This resolution goes on to indicate that, in asynchronous reactions, the driving and retarding components of the reaction force are mostly due the fast and slow-forming C-C bonds (elementary process) respectively, while in synchronous ones both elementary processes retard and drive the process concomitantly and equivalently.
Keywords
Diels-Alder reaction, AMADAR, reaction force analysis, natural population analysis, Hell-man-Feynman forces
Subject
Chemistry and Materials Science, Theoretical Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
