Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Neisseria Mucosa Does Not Inhibit the Growth of Neisseria gonorrhoeae

Said Abdellati
ORCID logo ,
Jolein Laumen
ORCID logo ,
Natalia Gonzalez
,
Sheeba Manoharan-Basil
ORCID logo ,
Christophe Van Dijck
,
Irith De Baetselier
ORCID logo ,
Delphine Martiny
,
Tessa De Block
,
Chris Kenyon
* ORCID logo
Version 1 : Received: 18 November 2021 / Approved: 19 November 2021 / Online: 19 November 2021 (12:23:16 CET)

A peer-reviewed article of this Preprint also exists.

Abdellati, S.; Laumen, J.; Gonzalez, N.; Manoharan-Basil, S.S.; Van Dijck, C.; De Baetselier, I.; Martiny, D.; de Block, T.; Kenyon, C. Neisseria mucosa Does Not Inhibit the Growth of Neisseria gonorrhoeae. Sci 2022, 4, 8. Abdellati, S.; Laumen, J.; Gonzalez, N.; Manoharan-Basil, S.S.; Van Dijck, C.; De Baetselier, I.; Martiny, D.; de Block, T.; Kenyon, C. Neisseria mucosa Does Not Inhibit the Growth of Neisseria gonorrhoeae. Sci 2022, 4, 8.

Abstract

Antibiotic-sparing treatments are required to prevent the further emergence of anti-microbial resistance in Neisseria gonorrhoeae. Commensal Neisseria species have previously been found to inhibit the growth of pathogenic Neisseria species. For example, a previous study found that 3 out of 5 historical isolates of Neisseria mucosa could inhibit the growth of N. gonorrhoeae. In this study, we used agar overlay assays to assess if 24 circulating and historical isolates of Neisseria mucosa could inhibit the growth of 28 circulating and historical isolates of N. gonorrhoeae. Although pitting around each colony of N. mucosa created an optical illusion of decreased growth of N. gonorrhoeae, we found no evidence of inhibition (n=24). In contrast, positive controls of Streptococcus pneumoniae and Escherichia coli demonstrated a strong inhibitory effect against the growth of N. gonorrhoeae.

Keywords

Agar over assay; bacterial inhibition; Neisseria gonorrhoeae; Neisseria mucosa

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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