Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cost-Effectiveness Analysis of the Daily HIV Pre-Exposure Prophylaxis in Men who Have Sex with Men in Barcelona

Francesc López Seguí
* ORCID logo ,
Unai Oyon Lerga
,
Laura Laguna Marmol
,
Pep Coll
,
Angels Andreu
,
Michael Meulbroek
,
Guillem López Casasnovas
ORCID logo ,
Oriol Estrada Cuxart
,
Jordi Ara Rey
,
Carles Quiñones
,
Felix Perez
,
Javier Fernandez
,
Angel Rivero
,
Bonaventura Clotet
Version 1 : Received: 16 November 2021 / Approved: 16 November 2021 / Online: 16 November 2021 (14:36:41 CET)

A peer-reviewed article of this Preprint also exists.

López Seguí, F.; Oyón Lerga, U.; Laguna Marmol, L.; Coll, P.; Andreu, A.; Meulbroek, M.; López Casasnovas, G.; Estrada Cuxart, O.; Ara Rey, J.; Quiñones, C.; et al. Cost-Effectiveness Analysis of the Daily HIV Pre-Exposure Prophylaxis in Men Who Have Sex with Men in Barcelona. PLOS ONE, 2023, 18, e0277571. https://doi.org/10.1371/journal.pone.0277571. López Seguí, F.; Oyón Lerga, U.; Laguna Marmol, L.; Coll, P.; Andreu, A.; Meulbroek, M.; López Casasnovas, G.; Estrada Cuxart, O.; Ara Rey, J.; Quiñones, C.; et al. Cost-Effectiveness Analysis of the Daily HIV Pre-Exposure Prophylaxis in Men Who Have Sex with Men in Barcelona. PLOS ONE, 2023, 18, e0277571. https://doi.org/10.1371/journal.pone.0277571.

Abstract

Introduction: Pre-Exposure Prophylaxis (PrEP) for HIV prevention has been implemented in several countries. Previous literature has shown that its cost-effectiveness (and, under some specifications, cost-saving character) is dependent on the reduction in price due to generics, the time-horizon and its effectiveness. The intervention has never been studied in Catalonia, a territory with extensive implementation. Methods: Economic evaluation of the implementation of HIV pre-exposition prophylaxis using administrative data from Men who have Sex with Men (MSM) who receive the treatment (at the generic price). A deterministic compartmental model and a social perspective with a micro-costing approach over the time horizon 2022-2062 are used. A baseline 86% effectiveness of PrEP is assumed. Results: Daily oral PrEP is found to be cost-saving: discounted savings in costs are attained after 16 years, and after 40 years they reach 81 million euros. In terms of health indicators, 10,322 additional discounted QALYs are generated by the intervention. Results are sensitive to sexual behavioral patterns among MSM, the price of PrEP (reduced if offered on-demand), its effectiveness and the discount rate. Conclusions: The use and promotion of PrEP in Catalonia is predicted to result in substantial health and monetary benefits because of reductions in HIV infections. Short-term investments in the promotion of PrEP will result in important cost-savings in the long term.

Keywords

Preexposure prophylaxis; transmission model; PrEP; economic evaluation; HIV; economic evaluation; health economics

Subject

Public Health and Healthcare, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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