Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Androgens, QT, Sex and Ventricular Repolarization: A Double-Edged Sword

Melissa Y.Y. Moey
,
Marie Wilkin
,
Estelle Gandjbakhch
,
Anne Bachelot
,
Baptiste Abbar
,
Bruno Pinna
,
Jean-Marc Simon
,
Christian Funck-Brentano
,
Joe-Elie Salem
*
Version 1 : Received: 15 August 2021 / Approved: 16 August 2021 / Online: 16 August 2021 (12:53:44 CEST)

How to cite: Moey, M.Y.; Wilkin, M.; Gandjbakhch, E.; Bachelot, A.; Abbar, B.; Pinna, B.; Simon, J.; Funck-Brentano, C.; Salem, J. Androgens, QT, Sex and Ventricular Repolarization: A Double-Edged Sword. Preprints 2021, 2021080338. https://doi.org/10.20944/preprints202108.0338.v1 Moey, M.Y.; Wilkin, M.; Gandjbakhch, E.; Bachelot, A.; Abbar, B.; Pinna, B.; Simon, J.; Funck-Brentano, C.; Salem, J. Androgens, QT, Sex and Ventricular Repolarization: A Double-Edged Sword. Preprints 2021, 2021080338. https://doi.org/10.20944/preprints202108.0338.v1

Abstract

The prevalence and incidence of cardiac pro-arrhythmic disorders are often influenced by sex due to specific effects on the QT interval. Androgens shorten QT, which may be protective against acquired long QT syndromes and their related arrhythmias in men such as torsade de pointes (TdP). On the other hand, androgens can potentiate Brugada and early repolarization syndromes, which are most prevalent in men. In this case series, we highlight four male patients with aborted SCD in the setting of abnormal testosterone status; two patients with TdP in a setting of testosterone deprivation (of which one drug-induced) and 2 patients with ventricular fibrillation associated with exogenous androgenic booster (Tribulus terrestris) intake. From this case series, we review the current available literature of the effects of androgen as a double-edged sword on the QTc interval and emphasize the importance of QTc monitoring in this subset of patients.

Keywords

testosterone; androgens; QT; Torsade de pointes; ventricular repolarization

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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