Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Serenoa repens (saw palmetto) for Lower Urinary Tract Symptoms (LUTS): The Evidence for Efficacy and Safety of Lipidosterolic Extracts. Part I.

Version 1 : Received: 2 July 2021 / Approved: 5 July 2021 / Online: 5 July 2021 (15:29:20 CEST)

A peer-reviewed article of this Preprint also exists.

Strum, S.B. Serenoa repens (Saw palmetto) for Lower Urinary Tract Symptoms (LUTS): The Evidence for Efficacy and Safety of Lipidosterolic Extracts. Part I. Uro 2021, 1, 118-138. Strum, S.B. Serenoa repens (Saw palmetto) for Lower Urinary Tract Symptoms (LUTS): The Evidence for Efficacy and Safety of Lipidosterolic Extracts. Part I. Uro 2021, 1, 118-138.

Abstract

Given the extent of this global analysis, this report will be presented in three sections. Part I will introduce LUTS. What are the demographics of LUTS? What symptoms are assessed by LUTS and how do we quantify LUTS? Why would a non-prescription item be a valuable consideration in LUTS treatment versus other treatment options? What is basic information about Serenoa repens and what defines a standardized LSESr product? What are the published trials that have affected the acceptability of Serenoa repens in the treatment of LUTS? Finally, a major portion of Part I will discuss the four major reviews of Serenoa repens versus LUTS that have influenced how it is accepted in the USA, in Europe, and other parts of the world. Part I, therefore, lays the groundwork and is foundational for the important findings relating to LUTS and Serenoa repens that will be presented in Parts II and III.

Keywords

lower urinary tract symptoms; LUTS; benign prostatic hyperplasia; BPH; saw palmetto; Serenoa repens; phytotherapy; lipidosterolic extract of Serenoa repens (LSESr); hexanic extract of Serenoa repens (HESr)

Subject

Medicine and Pharmacology, Immunology and Allergy

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