Novel Target Opportunities in Non-Metastatic Castrate Resistant Prostate Cancer

Stephanie Gleicher; Baylee A. Porter; Disharee Nath; Guanqun Li; Rakesh Khanna; Hanan Goldberg; Marcin Kortylewski; Gennady Bratslavsky; and Leszek Kotula

doi:10.20944/preprints202104.0287.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 9 April 2021 / Approved: 12 April 2021 / Online: 12 April 2021 (12:28:10 CEST)

Nearly one third of men will incur biochemical recurrence after treatment for localized prostate cancer. Androgen deprivation therapy (ADT) is the therapeutic mainstay, however almost all patients will eventually transition to a castrate resistant state (castrate resistant prostate cancer, CRPC). Subjects with CRPC generally develop symptomatic metastatic disease (mCRPC) and incur mortality several years later. Prior to metastatic disease, men acquire non-metastatic CRPC (nmCRPC) which lends the unique opportunity for intervention to delay disease progression and symptoms. This review addresses current therapies for nmCRPC, as well as novel therapeutics and pathway strategies targeting men with nmCRPC.

prostate cancer; castrate resistance, non-metastatic CRPC, clinical trial, epithelial mesenchymal transition, STAT3

Biology and Life Sciences, Biochemistry and Molecular Biology

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Novel Target Opportunities in Non-Metastatic Castrate Resistant Prostate Cancer

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