Version 1
: Received: 5 April 2021 / Approved: 6 April 2021 / Online: 6 April 2021 (10:00:21 CEST)
How to cite:
Leal, A.F.; Suarez, D.A.; Echeverri-Peña, O.Y.; Albarracín, S.L.; Alméciga-Díaz, C.J.; Espejo-Mojica, A.J. Sphingolipids and Cell Signaling: Relationship Between Health and Disease in the Central Nervous System. Preprints2021, 2021040161. https://doi.org/10.20944/preprints202104.0161.v1
Leal, A.F.; Suarez, D.A.; Echeverri-Peña, O.Y.; Albarracín, S.L.; Alméciga-Díaz, C.J.; Espejo-Mojica, A.J. Sphingolipids and Cell Signaling: Relationship Between Health and Disease in the Central Nervous System. Preprints 2021, 2021040161. https://doi.org/10.20944/preprints202104.0161.v1
Leal, A.F.; Suarez, D.A.; Echeverri-Peña, O.Y.; Albarracín, S.L.; Alméciga-Díaz, C.J.; Espejo-Mojica, A.J. Sphingolipids and Cell Signaling: Relationship Between Health and Disease in the Central Nervous System. Preprints2021, 2021040161. https://doi.org/10.20944/preprints202104.0161.v1
APA Style
Leal, A.F., Suarez, D.A., Echeverri-Peña, O.Y., Albarracín, S.L., Alméciga-Díaz, C.J., & Espejo-Mojica, A.J. (2021). Sphingolipids and Cell Signaling: Relationship Between Health and Disease in the Central Nervous System. Preprints. https://doi.org/10.20944/preprints202104.0161.v1
Chicago/Turabian Style
Leal, A.F., Carlos Javier Alméciga-Díaz and Angela Johana Espejo-Mojica. 2021 "Sphingolipids and Cell Signaling: Relationship Between Health and Disease in the Central Nervous System" Preprints. https://doi.org/10.20944/preprints202104.0161.v1
Abstract
Sphingolipids are lipids derived from an 18-carbons unsaturated amino alcohol, the sphingosine. Ceramide, sphingomyelins, sphingosine-1-phosphates, gangliosides and globosides, are part of this group of lipids that participate in important cellular roles such as structural part of plasmatic and organelle membranes maintaining their function and integrity, cell signaling response, cell growth, cell cycle, cell death, inflammation, cell migration and differentiation, autophagy, angiogenesis, immune system. The metabolism of these lipids involves a broad and complex network of reactions that convert one lipid into others through different specialized enzymes. Impairment of sphingolipids metabolism has been associated with several disorders, from several lysosomal storage diseases, known as sphingolipidoses, to polygenic diseases such as diabetes and Parkinson and Alzheimer diseases. Sphingolipids are mainly located in central nervous system, and their abundance and distribution depend on brain development state and cell type. Although several studies have expanded the knowledge about sphingolipids function both in health and disease, it is still necessary to continue their study to understand the cellular implications of novel sphingolipids. These studies will also contribute to the diagnosis and treatment of diseases in which these molecules are part of their pathophysiology. In this review, we summarize the main sphingolipid characteristics and current knowledge about the synthesis, catabolism, regulatory pathways, participation in action potential and ionic channels, among other relevant functions.
Keywords
Central Nervous System, GM2 Gangliosidoses, Sphingolipids, Sphingolipidosis.
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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