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SARS-CoV-2 Virion Stabilization by Zn Binding
Version 1
: Received: 24 May 2020 / Approved: 26 May 2020 / Online: 26 May 2020 (08:14:47 CEST)
Version 2 : Received: 9 August 2020 / Approved: 9 August 2020 / Online: 9 August 2020 (22:08:56 CEST)
Version 2 : Received: 9 August 2020 / Approved: 9 August 2020 / Online: 9 August 2020 (22:08:56 CEST)
How to cite: Morante, S.; La Penna, G.; Rossi, G. C.; Stellato, F. SARS-CoV-2 Virion Stabilization by Zn Binding. Preprints 2020, 2020050423. https://doi.org/10.20944/preprints202005.0423.v2 Morante, S.; La Penna, G.; Rossi, G. C.; Stellato, F. SARS-CoV-2 Virion Stabilization by Zn Binding. Preprints 2020, 2020050423. https://doi.org/10.20944/preprints202005.0423.v2
Abstract
Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.
Keywords
Sars-CoV2; Zn Finger; orf7a/orf8 and Theterin
Subject
Biology and Life Sciences, Biophysics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Commenter: Silvia Morante
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