Article
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Phylogenetic and Variant Analysis of 1,040 SARS-CoV-2 Genomes
Version 1
: Received: 24 May 2020 / Approved: 24 May 2020 / Online: 24 May 2020 (18:25:47 CEST)
How to cite: Rouchka, E. C.; Chariker, J. H.; Chung, D. Phylogenetic and Variant Analysis of 1,040 SARS-CoV-2 Genomes. Preprints 2020, 2020050396. https://doi.org/10.20944/preprints202005.0396.v1 Rouchka, E. C.; Chariker, J. H.; Chung, D. Phylogenetic and Variant Analysis of 1,040 SARS-CoV-2 Genomes. Preprints 2020, 2020050396. https://doi.org/10.20944/preprints202005.0396.v1
Abstract
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As part of testing efforts, whole genome sequencing of human isolates has resulted in over 1,600 complete genomes publicly available from GenBank. We have performed a comparative phylogenetic analysis of the sequences, in order to detect common mutations within the population. Analysis of variants occurring within the assembled genomes yields 417 variants occurring in at least 1% of the completed genomes, including 229 within the 5’ untranslated region (UTR), 152 within the 3’UTR, 2 within intergenic regions and 34 within coding sequences.
Keywords
SARS-CoV-2; COVID-19; coronavirus; variant analysis; phylogenetic analysis; viral evolution
Subject
Biology and Life Sciences, Virology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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