Version 1
: Received: 18 February 2020 / Approved: 19 February 2020 / Online: 19 February 2020 (11:47:26 CET)
How to cite:
Li, Y.; Jia, Y.; Hou, W.; Tan, H. Novel Morphological Alteration and Neural Pathway of NADPH Diaphorase Positivity in the Spinal Cord with Disc Herniation of Aged Dog: A Case Report. Preprints2020, 2020020280. https://doi.org/10.20944/preprints202002.0280.v1
Li, Y.; Jia, Y.; Hou, W.; Tan, H. Novel Morphological Alteration and Neural Pathway of NADPH Diaphorase Positivity in the Spinal Cord with Disc Herniation of Aged Dog: A Case Report. Preprints 2020, 2020020280. https://doi.org/10.20944/preprints202002.0280.v1
Li, Y.; Jia, Y.; Hou, W.; Tan, H. Novel Morphological Alteration and Neural Pathway of NADPH Diaphorase Positivity in the Spinal Cord with Disc Herniation of Aged Dog: A Case Report. Preprints2020, 2020020280. https://doi.org/10.20944/preprints202002.0280.v1
APA Style
Li, Y., Jia, Y., Hou, W., & Tan, H. (2020). Novel Morphological Alteration and Neural Pathway of NADPH Diaphorase Positivity in the Spinal Cord with Disc Herniation of Aged Dog: A Case Report. Preprints. https://doi.org/10.20944/preprints202002.0280.v1
Chicago/Turabian Style
Li, Y., Wei Hou and Huibing Tan. 2020 "Novel Morphological Alteration and Neural Pathway of NADPH Diaphorase Positivity in the Spinal Cord with Disc Herniation of Aged Dog: A Case Report" Preprints. https://doi.org/10.20944/preprints202002.0280.v1
Abstract
Neuronal lesion or injury is a traditional approach to investigate neural circuit. Is any new neural pathway or new neurodegeneration related central nerve system injury? Spinal disc herniation can cause the spinal cord injury. However, the histological examination is still lack. It happened that a case of spinal disc herniation of a 10-year old dog was examined with NADPH diaphorase (N-d) histology. We did not find the N-d neurodegenerative aberrant in the tissue of the mid-rostral lumber segment besides the metamorphoses by the compression of the disc herniation. However, the severe neuropathological changes majorly occurred in the lumbosacral spinal cord. We found more diverse neurodegenerative alterations: the aging-related N-d body (ANB), megaloneurite and N-d homogeneous formazan globule in the lumbosacral spinal cord. We also found that a new circuit pathway (intermedial collateral pathway) showed by a megaloneurite between the lateral collateral pathway and the medial collateral pathway. The enormous notch caused by spinal disc herniation located at the mid-rostral lumber segments. The aging-related neurodegeneration occurred the specific lumbosacral segments. The homogeneous formazan globule was round or oval homogeneous N-d positivity which distributed in the gray matter and dorsal column. In the medulla oblongata, ANBs were revealed in the gracile nucleus, nucleus reticularis lateralis (ventrolateral spinal trigeminal nucleus) and middle of the spinal trigeminal nucleus.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
