A Smith, G. Calcium, Actomyosin Kinetics, Myosin Binding Protein-c and Hypertrophic Cardiomyopathy. Journal of Integrative Cardiology, 2019, 5. https://doi.org/10.15761/jic.1000277.
A Smith, G. Calcium, Actomyosin Kinetics, Myosin Binding Protein-c and Hypertrophic Cardiomyopathy. Journal of Integrative Cardiology, 2019, 5. https://doi.org/10.15761/jic.1000277.
A Smith, G. Calcium, Actomyosin Kinetics, Myosin Binding Protein-c and Hypertrophic Cardiomyopathy. Journal of Integrative Cardiology, 2019, 5. https://doi.org/10.15761/jic.1000277.
A Smith, G. Calcium, Actomyosin Kinetics, Myosin Binding Protein-c and Hypertrophic Cardiomyopathy. Journal of Integrative Cardiology, 2019, 5. https://doi.org/10.15761/jic.1000277.
Abstract
In an attempt to correct misunderstandings this article brings together the observations on Calcium, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy in the basic function of cardiac muscle. A finding of many years ago is reiterated in a novel enzyme kinetic format with defined rate limiting step which makes CaATP the apparent substrate of the actomyosin cross-bridge. The relationship of these kinetics to recent observations on disruption of myosin binding protein-C is described along with how this bears on the understanding of the related cardiomyopathies.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
