Version 1
: Received: 11 September 2018 / Approved: 12 September 2018 / Online: 12 September 2018 (01:20:54 CEST)
How to cite:
Martínez-Magaña, J. J.; Gonzalez-Castro, T. B.; Genis-Mendoza, A. D.; Tovilla-Zarate, C. A.; Juarez-Rojop, I.; Saucedo-Uribe, E.; Lanzagorta, N.; Escamilla, M.; Macías-Kauffer, L.; Nicolini, H. An analysis on Dual Diagnosis Revealed a Possible deviation of Schizophrenia Polygenic Risk Score by Mexican Amerindian Ancestry. Preprints2018, 2018090206. https://doi.org/10.20944/preprints201809.0206.v1
Martínez-Magaña, J. J.; Gonzalez-Castro, T. B.; Genis-Mendoza, A. D.; Tovilla-Zarate, C. A.; Juarez-Rojop, I.; Saucedo-Uribe, E.; Lanzagorta, N.; Escamilla, M.; Macías-Kauffer, L.; Nicolini, H. An analysis on Dual Diagnosis Revealed a Possible deviation of Schizophrenia Polygenic Risk Score by Mexican Amerindian Ancestry. Preprints 2018, 2018090206. https://doi.org/10.20944/preprints201809.0206.v1
Martínez-Magaña, J. J.; Gonzalez-Castro, T. B.; Genis-Mendoza, A. D.; Tovilla-Zarate, C. A.; Juarez-Rojop, I.; Saucedo-Uribe, E.; Lanzagorta, N.; Escamilla, M.; Macías-Kauffer, L.; Nicolini, H. An analysis on Dual Diagnosis Revealed a Possible deviation of Schizophrenia Polygenic Risk Score by Mexican Amerindian Ancestry. Preprints2018, 2018090206. https://doi.org/10.20944/preprints201809.0206.v1
APA Style
Martínez-Magaña, J. J., Gonzalez-Castro, T. B., Genis-Mendoza, A. D., Tovilla-Zarate, C. A., Juarez-Rojop, I., Saucedo-Uribe, E., Lanzagorta, N., Escamilla, M., Macías-Kauffer, L., & Nicolini, H. (2018). An analysis on Dual Diagnosis Revealed a Possible deviation of Schizophrenia Polygenic Risk Score by Mexican Amerindian Ancestry. Preprints. https://doi.org/10.20944/preprints201809.0206.v1
Chicago/Turabian Style
Martínez-Magaña, J. J., Luis Macías-Kauffer and Humberto Nicolini. 2018 "An analysis on Dual Diagnosis Revealed a Possible deviation of Schizophrenia Polygenic Risk Score by Mexican Amerindian Ancestry" Preprints. https://doi.org/10.20944/preprints201809.0206.v1
Abstract
In order to summarized the polygenic background of psychiatric diseases, polygenic risk scores (PRS) have been developed. Recently, PRS have been use to predict patients with higher comorbidities in psychiatric diseases, like dual diagnosis. PRS are principally derived in analysis of Caucasian and Asian populations, we are not aware of how this PRS could be applied in populations with high admixture. In order to explored this, the present work has the aim to analyzed if previous calculated PRS for psychiatric diseases could predict dual diagnosis in Mexican population, and also, if PRS calculation could be influenced by Mexican Amerindian (MA) global ancestry. We performed PRS calculation, using PRSice, with summary genome-wide association statistics previously published for psychiatric diseases, and also, performed Nagelkerke correlation test in order to established if PRS are correlated with dual diagnosis. We found that dual diagnosis could be predicted by major depressive disorder polygenic risk score. Nevertheless, schizophrenia polygenic risk score is highly correlated with global MA ancestry, independently of the schizophrenia diagnosis. Our results reinforced the notion that PRS calculation could be deviated by the MA global ancestry, nevertheless analysis on larger sample sizes are required in order to clarified this issue.
Medicine and Pharmacology, Psychiatry and Mental Health
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.