Review
Version 1
Preserved in Portico This version is not peer-reviewed
Anomeric Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs
Version 1
: Received: 25 June 2018 / Approved: 25 June 2018 / Online: 25 June 2018 (15:08:22 CEST)
A peer-reviewed article of this Preprint also exists.
Park, S.S.; Hsieh, H.-W.; Gervay-Hague, J. Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. Molecules 2018, 23, 1742. Park, S.S.; Hsieh, H.-W.; Gervay-Hague, J. Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. Molecules 2018, 23, 1742.
Abstract
Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge. With advances in chemical and enzymatic carbohydrate synthesis, the availability of complex carbohydrates is increasing and developing methods for stereoselective conjugation these polar head groups to proteins and lipids is critically important for pharmaceutical applications. The aim of this review is to provide an overview of commonly employed strategies for installing a functionalized linker at the anomeric position as well as examples of further transformations that have successfully led to glycoconjugation to vaccine constructs for biological evaluation as carbohydrate-based therapeutics.
Keywords
Carbohydrates; glycosylation; glycosides; glycoconjugates; anomeric functionalization
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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