Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Prenatal Exposure to Ambient Pesticides and Adverse Birth Outcomes in Agricultural Regions of California

Chenxiao Ling
,
Zeyan Liew
ORCID logo ,
Ondine S. von Ehrenstein
,
Julia E. Heck
,
Andrew S. Park
,
Xin Cui
,
Myles Cockburn
,
Jun Wu
,
Beate Ritz
*
Version 1 : Received: 24 June 2018 / Approved: 25 June 2018 / Online: 25 June 2018 (12:44:14 CEST)

A peer-reviewed article of this Preprint also exists.

Ling, C.; Liew, Z.; von Ehrenstein, O.S.; Heck, J.E.; Park, A.S.; Cui, X.; Cockburn, M.; Wu, J.; Ritz, B. Prenatal Exposure to Ambient Pesticides and Preterm Birth and Term Low Birthweight in Agricultural Regions of California. Toxics 2018, 6, 41. Ling, C.; Liew, Z.; von Ehrenstein, O.S.; Heck, J.E.; Park, A.S.; Cui, X.; Cockburn, M.; Wu, J.; Ritz, B. Prenatal Exposure to Ambient Pesticides and Preterm Birth and Term Low Birthweight in Agricultural Regions of California. Toxics 2018, 6, 41.

Abstract

Findings from studies of prenatal exposure to pesticides and adverse birth outcomes have been equivocal so far. We examined prenatal exposure to agricultural pesticides in relation to preterm birth and term low birthweight, respectively, in children born between 1998 and 2010 randomly selected from California birth records. We estimated residential exposures to agriculturally applied pesticides within 2 km of residential addresses at birth by pregnancy trimester for 17 individual pesticides and 3 chemical classes (organophosphates, pyrethroids, and carbamates). Among maternal addresses located within 2 km of any agricultural pesticide application, we identified 24,693 preterm and 220,297 term births, and 4,412 term low birthweight and 194,732 term normal birthweight infants. First or second trimester exposures to individual pesticides (e.g., glyphosates, paraquat, imidacloprid) or exposures to 2+ pesticides in the three chemical classes were associated with small increases (3-7%) in risk for preterm birth; associations were stronger for female offspring. We did not find associations between term low birthweight and exposures to pesticides other than for myclobutanil (OR: 1.11; 95% CI: 1.04-1.20) and possibly pyrethroids as a class. Our improved exposure assessment revealed that first and second trimester exposures to pesticides were associated with preterm delivery but few affected term low birthweight.

Keywords

agricultural pesticides; residential proximity; adverse birth outcomes; preterm birth; low birthweight; pregnancy

Subject

Biology and Life Sciences, Insect Science

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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