Version 1
: Received: 26 April 2018 / Approved: 27 April 2018 / Online: 27 April 2018 (09:00:55 CEST)
How to cite:
Bulfone, T.C.; Samuel, S.P.; Bickler, P.L.; Lewin, M.R. Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite. Preprints2018, 2018040358. https://doi.org/10.20944/preprints201804.0358.v1
Bulfone, T.C.; Samuel, S.P.; Bickler, P.L.; Lewin, M.R. Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite. Preprints 2018, 2018040358. https://doi.org/10.20944/preprints201804.0358.v1
Bulfone, T.C.; Samuel, S.P.; Bickler, P.L.; Lewin, M.R. Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite. Preprints2018, 2018040358. https://doi.org/10.20944/preprints201804.0358.v1
APA Style
Bulfone, T.C., Samuel, S.P., Bickler, P.L., & Lewin, M.R. (2018). Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite. Preprints. https://doi.org/10.20944/preprints201804.0358.v1
Chicago/Turabian Style
Bulfone, T.C., Philip L. Bickler and Matthew R. Lewin. 2018 "Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite" Preprints. https://doi.org/10.20944/preprints201804.0358.v1
Abstract
The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major therapeutic challenge. Small molecule therapeutics (SMTs) have been proposed as potential pre-referral treatments for snakebite to help address this gap. Herein, we discuss the characteristics, potential uses and development of SMTs as potential treatments for snakebite envenomation. We focus on SMTs that are secretory phospholipase A2 (sPLA2) inhibitors and metalloprotease (MP) inhibitors.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.