Preprint Concept Paper Version 1 Preserved in Portico This version is not peer-reviewed

Maristem - Stem Cells of Marine/Aquatic Invertebrates: From Basic Research to Innovative Applications

Loriano Ballarin
* ORCID logo ,
Baruch Rinkevich
ORCID logo ,
Kerstin Bartscherer
,
Artur Burzynski
ORCID logo ,
Sebastien Cambier
,
Matteo Cammarata
,
Isabelle Domart-Coulon
,
Damjana Drobne
ORCID logo ,
Juanma Encinas
,
Uri Frank
,
Anne-Marie Geneviere
,
Bert Hobmayer
,
Helike Löhelaid
,
Daniel Lyons
,
Pedro Martinez
ORCID logo ,
Paola Oliveri
,
Lorena Peric
,
Stefano Piraino
ORCID logo ,
Andreja Ramšak
,
Sebastian Rakers
,
Fabian Rentzsch
,
Amalia Rosner
,
Tiago Henriques da Silva
,
Ildiko Somorjai
ORCID logo ,
Sherif Suleiman
,
Ana Varela Coelho
ORCID logo
Version 1 : Received: 23 January 2018 / Approved: 24 January 2018 / Online: 24 January 2018 (04:14:56 CET)

A peer-reviewed article of this Preprint also exists.

Ballarin, L.; Rinkevich, B.; Bartscherer, K.; Burzynski, A.; Cambier, S.; Cammarata, M.; Domart-Coulon, I.; Drobne, D.; Encinas, J.; Frank, U.; Geneviere, A.-M.; Hobmayer, B.; Löhelaid, H.; Lyons, D.; Martinez, P.; Oliveri, P.; Peric, L.; Piraino, S.; Ramšak, A.; Rakers, S.; Rentzsch, F.; Rosner, A.; Silva, T.H.; Somorjai, I.; Suleiman, S.; Coelho, A.V. Maristem—Stem Cells of Marine/Aquatic Invertebrates: From Basic Research to Innovative Applications. Sustainability 2018, 10, 526. Ballarin, L.; Rinkevich, B.; Bartscherer, K.; Burzynski, A.; Cambier, S.; Cammarata, M.; Domart-Coulon, I.; Drobne, D.; Encinas, J.; Frank, U.; Geneviere, A.-M.; Hobmayer, B.; Löhelaid, H.; Lyons, D.; Martinez, P.; Oliveri, P.; Peric, L.; Piraino, S.; Ramšak, A.; Rakers, S.; Rentzsch, F.; Rosner, A.; Silva, T.H.; Somorjai, I.; Suleiman, S.; Coelho, A.V. Maristem—Stem Cells of Marine/Aquatic Invertebrates: From Basic Research to Innovative Applications. Sustainability 2018, 10, 526.

Abstract

The “stem cells” discipline represents one of the most dynamic areas in biomedicine. While adult marine/aquatic invertebrate stem cell (MISC) biology is of prime research and medical interest, studies on stem cells from organisms outside the classical vertebrate (e.g., human, mouse, zebrafish) and invertebrate (e.g., Drosophila, Caenorhabditis) models have not been pursued vigorously. Marine/aquatic invertebrates constitute the largest biodiversity and the widest phylogenetic radiation on Earth, from morphologically simple organisms (e.g. sponges, cnidarians), to the more complex mollusks, crustaceans, echinoderms and protochordates. These organisms illustrate a kaleidoscope of MISC-types that participate in the production of a large number of novel bioactive-molecules, many of which are of significant potential interest for human health. MISCs further participate in aging and regeneration phenomena, including whole-body regeneration. For years, the European MISC-community has been highly fragmented and scarce ties were established with biomedical industries in attempts to harness MISCs for human welfare. Thus, it is important to: i) consolidate the fragmented European community working on MISCs; ii) promote and coordinate European research on MISC biology; iii) stimulate young researchers to embark on research in MISC-biology; iv) develop, validate, and network novel MISC tools and methodologies; v) establish the MISC discipline as a forefront interest of biomedical disciplines, including nanobiomedicine; vi) establish collaborations with industries to exploit MISCs as sources of bioactive molecules. In order to fill the recognised gaps, the EC-COST Action 16203 “MARISTEM”, has recently been launched. At its initial stage the consortium unites 26 scientists from EC countries, Cooperating countries and Near Neighbor Countries.

Keywords

aging; bioactive molecules; blue biotechnology; cancer; cell culture; COST Action; Europe; marine/aquatic invertebrates; regeneration; stem cells

Subject

Biology and Life Sciences, Cell and Developmental Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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