Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Thyroid Nodules in Centenarians: Prevalence and Relationship to Lifestyle Characteristics and Dietary Habits

Yao Yao
ORCID logo ,
Xianghui Chen
,
Shengzheng Wu
,
Liang Guo
,
Hao Zhang
,
Qiao Zhu
,
Jie Tang
,
Fuxin Luan
,
Yali Zhao
,
Faqin Lv
* ,
Yao He
*
Version 1 : Received: 12 January 2018 / Approved: 16 January 2018 / Online: 16 January 2018 (10:04:38 CET)

How to cite: Yao, Y.; Chen, X.; Wu, S.; Guo, L.; Zhang, H.; Zhu, Q.; Tang, J.; Luan, F.; Zhao, Y.; Lv, F.; He, Y. Thyroid Nodules in Centenarians: Prevalence and Relationship to Lifestyle Characteristics and Dietary Habits. Preprints 2018, 2018010138. https://doi.org/10.20944/preprints201801.0138.v1 Yao, Y.; Chen, X.; Wu, S.; Guo, L.; Zhang, H.; Zhu, Q.; Tang, J.; Luan, F.; Zhao, Y.; Lv, F.; He, Y. Thyroid Nodules in Centenarians: Prevalence and Relationship to Lifestyle Characteristics and Dietary Habits. Preprints 2018, 2018010138. https://doi.org/10.20944/preprints201801.0138.v1

Abstract

Thyroid nodules (TNs) are common thyroid lesions in older population. Few studies focused on the prevalence of TNs and its relationship to lifestyle characteristics and dietary habits in centenarians. The current study aimed to determine the prevalence of TNs in Chinese centenarians using high-resolution ultrasound equipment and investigate its relationship to lifestyles and dietary habits. The current study was part of China Hainan Centenarian Cohort Study (CHCCS) which conducted in Hainan, an iodine sufficient region in China. A total of 874 permanent residents aged 100 years or older (mean age, 102.8 ± 2.8 years) without any missing data were included in the analysis. Among the participants, 649 of them were detected at least one thyroid nodule under the ultrasound examinations. The overall prevalence rate of TNs was 74.3%. The prevalence of TNs was higher in participants who were females, hypertension, diabetes, and underweight than their counterparts. Multivariate logistic regression analyses showed that being female, hypertension, diabetes, betel quid consumption, red meat consumption were independent risk factors, while being underweight, and nut consumption were independent protective factors for TNs. Our findings indicate that the presence of thyroid nodules was highly prevalent in Chinese centenarians, particularly in females. In addition to gender, hypertension, diabetes, and underweight, the presence of TNs was independently associated with betel quid, red meat, and nut consumptions. Further prospective studies are warranted to verify these associations in population from different age strata, races, cultures, and iodine backgrounds.

Keywords

thyroid nodules; ultrasound; lifestyle; dietary; betel quid; red meat; nut; centenarians

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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