Version 1
: Received: 10 April 2017 / Approved: 11 April 2017 / Online: 11 April 2017 (06:16:22 CEST)
How to cite:
Zhang, X.; Pan, G.; Zhang, Z.; Tao, S. Vitamin D Deficiency Increases the Risk of Diabetic Retinopathy: A Meta-Analysis of Observational Studies. Preprints2017, 2017040059. https://doi.org/10.20944/preprints201704.0059.v1
Zhang, X.; Pan, G.; Zhang, Z.; Tao, S. Vitamin D Deficiency Increases the Risk of Diabetic Retinopathy: A Meta-Analysis of Observational Studies. Preprints 2017, 2017040059. https://doi.org/10.20944/preprints201704.0059.v1
Zhang, X.; Pan, G.; Zhang, Z.; Tao, S. Vitamin D Deficiency Increases the Risk of Diabetic Retinopathy: A Meta-Analysis of Observational Studies. Preprints2017, 2017040059. https://doi.org/10.20944/preprints201704.0059.v1
APA Style
Zhang, X., Pan, G., Zhang, Z., & Tao, S. (2017). Vitamin D Deficiency Increases the Risk of Diabetic Retinopathy: A Meta-Analysis of Observational Studies. Preprints. https://doi.org/10.20944/preprints201704.0059.v1
Chicago/Turabian Style
Zhang, X., Zeng-Li Zhang and Shasha Tao. 2017 "Vitamin D Deficiency Increases the Risk of Diabetic Retinopathy: A Meta-Analysis of Observational Studies" Preprints. https://doi.org/10.20944/preprints201704.0059.v1
Abstract
Background: Diabetic retinopathy (DR) is one of the most prominent pathological microvascular complications in diabetes. A series of studies reported that vitamin D deficiency was associated with increased prevalence of retinopathy in diabetic patients but the results were inconsistent. In this study we focused on evaluating the relationship between vitamin D deficiency and DR by conducting a meta-analysis of observational studies. Methods: Systematic computerized searches were performed in PubMed, MEDLINE, and the Cochrane Library for relevant original articles till November 20, 2016. The pooled odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated to assess the associated value of vitamin D deficiency to the risk of DR. 9 studies including 6332 participants were subjected to final analysis. Results: The results indicated that vitamin D deficiency increases the risk of DR (OR = 1.57, 95% CI 1.32-1.87) with a little heterogeneity (I2 = 23%). In addition, the subgroup analysis demonstrated that there were obvious heterogeneities in T2DM (I2 = 47.8%). Sensitivity analysis showed that the results were relatively stable and reliable. Conclusion: our meta-analysis demonstrated that vitamin D deficiency could increase the risk of DR.
Keywords
Keywords: vitamin D deficiency; diabetic retinopathy; meta-analysis.
Subject
Biology and Life Sciences, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
