Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

Ana Flávia Costa da Silveira Oliveira; Róbson Ricardo Teixeira; André Silva de Oliveira; Ana Paula Martins de Souza; Milene Lopes da Silva; Sérgio Oliveira de Paula

doi:10.20944/preprints201703.0118.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 15 March 2017 / Approved: 16 March 2017 / Online: 16 March 2017 (09:42:52 CET)

Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of infection and thousands of deaths worldwide. Therefore, several investigations were conducted over the past few years to find antiviral compounds for the treatment of DENV and CHIKV infections. One attractive strategy is the screening of compounds that target enzymes involved in the replication of both DENV and CHIKV. In this review, we describe advances in the evaluation of natural products targeting the enzymes involved in the replication of these viruses.

dengue; chikungunya; virus enzymes; antiviral; natural products

Chemistry and Materials Science, Medicinal Chemistry

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Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

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