Preprint Article Version 1 NOT YET PEER-REVIEWED

A Study on Antitumor Effect of 1,3,4-Thiadiazole Derivatives in Prostate and Breast Cancer Cell Lines (In Vitro)

Version 1 : Received: 9 March 2017 / Approved: 10 March 2017 / Online: 10 March 2017 (10:11:56 CET)

How to cite: Hassan, F.; Hairunisa, N.; Mohammed, S.; Yousif, E. A Study on Antitumor Effect of 1,3,4-Thiadiazole Derivatives in Prostate and Breast Cancer Cell Lines (In Vitro). Preprints 2017, 2017030053 (doi: 10.20944/preprints201703.0053.v1). Hassan, F.; Hairunisa, N.; Mohammed, S.; Yousif, E. A Study on Antitumor Effect of 1,3,4-Thiadiazole Derivatives in Prostate and Breast Cancer Cell Lines (In Vitro). Preprints 2017, 2017030053 (doi: 10.20944/preprints201703.0053.v1).

Abstract

5-(4-aminophenyl )-2-amino -1,3,4-thiadiazole was prepared by reaction of Thiosemicarbazide with 4-amino benzoic acid under reflux condition for 7 hours. The compound which has been synthesized successfully was subjected to addition reaction with 4-(Dimethylamino) benzaldehyde under reflux condition for 6 hours to synthesize Schiff bases. These compounds was characterized by using FTIR) and evaluated for their anticancer activity. The effect of (1, 3, 4-thiadiazole derivative) on the activity of malignant cells was studied by using different types of cell lines [Breast cancer, and human prostate cancer]. And was used the Electron microscope to show that the effect of the derivative on the cancer cells before and after 3 days of the injection time. It was found that the Schiff base of thiadiazole-1,3,4-(Dimethylamino)benzylidineamino]- [4-2-phenyl]amino was effective in reducing the size and density of malignant cells. That of 46.7 while in breast ) 145(DUprostate for growth inhibition produce of equal 85.9 µg/ml.

Subject Areas

1,3,4-Thiadiazole; 1,2,4-Triazole; synthesis; MTT assay; Cytotoxicity of Schiff base

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