Preprint Article Version 1 NOT YET PEER-REVIEWED

Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing Ball Mill Technique: Green Sustainable Process

Version 1 : Received: 3 February 2017 / Approved: 5 February 2017 / Online: 5 February 2017 (09:22:49 CET)

A peer-reviewed article of this Preprint also exists.

Shahid, A.; Ahmed, N.S.; Saleh, T.S.; Al-Thabaiti, S.A.; Basahel, S.N.; Schwieger, W.; Mokhtar, M. Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing a Ball Mill Technique: A Green Sustainable Process. Catalysts 2017, 7, 84. Shahid, A.; Ahmed, N.S.; Saleh, T.S.; Al-Thabaiti, S.A.; Basahel, S.N.; Schwieger, W.; Mokhtar, M. Solvent-Free Biginelli Reactions Catalyzed by Hierarchical Zeolite Utilizing a Ball Mill Technique: A Green Sustainable Process. Catalysts 2017, 7, 84.

Journal reference: Catalysts 2017, 7, 84
DOI: 10.3390/catal7030084

Abstract

A sustainable green one pot procedure for the synthesis of dihydropyrimidinones (DHPMs) derivatives by a three-component reaction of β-ketoester derivatives, aldehyde and urea or thiourea over the alkali-treated H-ZSM-5 zeolite under ball-milling has been developed. The product was isolated by simple washing of the crude reaction residue with ethyl acetate followed by evaporation of solvent. The hierachical zeolite catalyst (MFI27_6) showed high yield (86–96%) of dihydropyrimidinones (DHPMs), in very short time (10-30 min). The catalyst is recycled for subsequent reactions in four runs without appreciable loss of activity and high yields of products provide efficient protocol for Biginelli reactions.

Subject Areas

Hierarchical; MFI27; Biginelli; dihydropyrimidinones; Ball mill

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