PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Evolution of Serum 25OHD in Response to Vitamin D3 Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality
Version 1
: Received: 30 January 2017 / Approved: 31 January 2017 / Online: 31 January 2017 (12:01:31 CET)
How to cite:
Bonjour, J.; Dontot-Payen, F.; Rouy, E.; Walrand, S.; Rousseau, B. Evolution of Serum 25OHD in Response to Vitamin D3 Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality. Preprints2017, 2017010135. https://doi.org/10.20944/preprints201701.0135.v1
Bonjour, J.; Dontot-Payen, F.; Rouy, E.; Walrand, S.; Rousseau, B. Evolution of Serum 25OHD in Response to Vitamin D3 Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality. Preprints 2017, 2017010135. https://doi.org/10.20944/preprints201701.0135.v1
Bonjour, J.; Dontot-Payen, F.; Rouy, E.; Walrand, S.; Rousseau, B. Evolution of Serum 25OHD in Response to Vitamin D3 Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality. Preprints2017, 2017010135. https://doi.org/10.20944/preprints201701.0135.v1
APA Style
Bonjour, J., Dontot-Payen, F., Rouy, E., Walrand, S., & Rousseau, B. (2017). Evolution of Serum 25OHD in Response to Vitamin D<sub>3</sub> Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality. Preprints. https://doi.org/10.20944/preprints201701.0135.v1
Chicago/Turabian Style
Bonjour, J., Stephane Walrand and Brigitte Rousseau. 2017 "Evolution of Serum 25OHD in Response to Vitamin D<sub>3</sub> Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality" Preprints. https://doi.org/10.20944/preprints201701.0135.v1
Abstract
A 24 week-controlled trial was conducted in menopausal women (mean age:61.5) to assess serum 25-hydroyvitaminD (s25OHD) evolution in relation to three interdependent determinants: doses of supplemented (Suppl.) vitamin D3 (VitD3); baseline status; seasonality. Participants were randomized into 3 groups (Gr): Gr.Suppl.0, time-controls maintaining dietary habits; Gr.Suppl.5 and Gr.Suppl.10 consuming one and two 125 g servings of VitD3-fortified yogurts with 5 and 10 µg daily doses, respectively. The 16 intervention-weeks lasted from early-January to mid-August, the 8 follow-up-weeks from late-August to mid-October. Before enrollment, subjects were randomized into two s25OHD strata: “Low stratum (LoStr)“: 25-50 nmol/L; “High stratum (HiStr)“: >50-75 nmol/L. All enrolled participants remained compliant until study end: Gr.Suppl.0 (n=45), Gr.Suppl.5 (n=44) Gr.Suppl.10 (n=44). Over the 16 intervention and 8 follow-up weeks, s25OHD increased in both supplemented groups, more in Gr.Suppl.10 than Gr.Suppl.5. The constant rate of s25OHD per supplemental VitD3 microgram was greater in LoStr than HiStr. s25OHD increase was greater with late (mid-March) than early (mid-January) inclusion. In conclusion, this randomized trial demonstrates: -a dose-dependent s25OHD improvement related to fortified yogurt consumption; -an inversely baseline-dependent increase in s25OHD; -a seasonal effect that highlights the importance of vitamin D3 supplementation during winter, even at 5µg/d, in healthy menopausal women.
Medicine and Pharmacology, Dietetics and Nutrition
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
