Version 1
: Received: 17 January 2017 / Approved: 19 January 2017 / Online: 19 January 2017 (01:52:00 CET)
How to cite:
Pan, J.; Li, N.; Tang, Q.; Li, G.; Hou, Y.; Wang, L.; Yu, W. Gelatin Nanoparticles Loaded with PMX-53 Prevents Alveolar Bone Loss in Miniature Swines Model of Periodontitis. Preprints2017, 2017010083. https://doi.org/10.20944/preprints201701.0083.v1
Pan, J.; Li, N.; Tang, Q.; Li, G.; Hou, Y.; Wang, L.; Yu, W. Gelatin Nanoparticles Loaded with PMX-53 Prevents Alveolar Bone Loss in Miniature Swines Model of Periodontitis. Preprints 2017, 2017010083. https://doi.org/10.20944/preprints201701.0083.v1
Pan, J.; Li, N.; Tang, Q.; Li, G.; Hou, Y.; Wang, L.; Yu, W. Gelatin Nanoparticles Loaded with PMX-53 Prevents Alveolar Bone Loss in Miniature Swines Model of Periodontitis. Preprints2017, 2017010083. https://doi.org/10.20944/preprints201701.0083.v1
APA Style
Pan, J., Li, N., Tang, Q., Li, G., Hou, Y., Wang, L., & Yu, W. (2017). Gelatin Nanoparticles Loaded with PMX-53 Prevents Alveolar Bone Loss in Miniature Swines Model of Periodontitis. Preprints. https://doi.org/10.20944/preprints201701.0083.v1
Chicago/Turabian Style
Pan, J., Liuran Wang and Weixian Yu. 2017 "Gelatin Nanoparticles Loaded with PMX-53 Prevents Alveolar Bone Loss in Miniature Swines Model of Periodontitis" Preprints. https://doi.org/10.20944/preprints201701.0083.v1
Abstract
Periodontitis is a chronic inflammatory disease which results in the destruction of the tooth’ s supporting tissues and the alveolar bone resorption. The complement becomes a major link between infection and inflammatory pathology including periodontitis. Gingipians as important virulence factors of P. gingivalis have the activity of C5 convertase, could cleave C5 into fully functional C5a to activate C5aR. The above process could be blocked by the C5aR antagonist (PMX-53) to suppress local periodontal inflammation, and then achieves the purpose of treatment of periodontitis. Nanoparticles incorporated within gelatin are promising carrier system for drug delivery in recent years. This study aimed to investigate whether gelatin nanoparticles loaded with PMX-53 prevents alveolar bone resorption in miniature swines model of periodontitis. Four miniature swines were placed ligatures around the maxillary and mandibular fourth premolar and first molar on both sides for seven weeks to induce periodontitis. Then, animals were assigned randomly to four groups: minocycline-treated group, gelatin with PMX53-treated group, gelatin-treated group and a sham control group. They were treated with 1ml related drugs respectively, into gingival sulcusl for 4 times at one-week intervals. We showed that local treatments with gelatin nanoparticles loaded with PMX-53 could inhibit alveolar bone loss of periodontitis. Our study revealed that gelatin nanoparticles loaded with PMX-53 prevented alveolar bone resorption miniature swines model of periodontitis. In addition, provided proof-of-concept for local targeting of gelatin nanoparticles loaded with PMX-53 as a powerful candidate for the treatment of periodontitis.
Keywords
periodontitis; PMX-53; miniature swines
Subject
Medicine and Pharmacology, Dentistry and Oral Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: pei
The commenter has declared there is no conflict of interests.
we are from a new Journal of dentistry and we wonder if you would be interested in publishing this paper in our peer reviewed journal ?
warm regards