Version 1
: Received: 31 December 2016 / Approved: 2 January 2017 / Online: 2 January 2017 (18:14:59 CET)
How to cite:
Ali, R.H.; Abdeltawab, N.F.; Hady, O.A.; Amin, M.A. Synergistic Effect of Coadministration of Haemophilus influenzae and Neisseria meningitidis Vaccines on Immune Responses to Meningitis in Mouse Model. Preprints2017, 2017010010. https://doi.org/10.20944/preprints201701.0010.v1
Ali, R.H.; Abdeltawab, N.F.; Hady, O.A.; Amin, M.A. Synergistic Effect of Coadministration of Haemophilus influenzae and Neisseria meningitidis Vaccines on Immune Responses to Meningitis in Mouse Model. Preprints 2017, 2017010010. https://doi.org/10.20944/preprints201701.0010.v1
Ali, R.H.; Abdeltawab, N.F.; Hady, O.A.; Amin, M.A. Synergistic Effect of Coadministration of Haemophilus influenzae and Neisseria meningitidis Vaccines on Immune Responses to Meningitis in Mouse Model. Preprints2017, 2017010010. https://doi.org/10.20944/preprints201701.0010.v1
APA Style
Ali, R.H., Abdeltawab, N.F., Hady, O.A., & Amin, M.A. (2017). Synergistic Effect of Coadministration of <em>Haemophilus influenzae</em> and <em>Neisseria meningitidis</em> Vaccines on Immune Responses to Meningitis in Mouse Model. Preprints. https://doi.org/10.20944/preprints201701.0010.v1
Chicago/Turabian Style
Ali, R.H., Osama A. Hady and Magdy A. Amin. 2017 "Synergistic Effect of Coadministration of <em>Haemophilus influenzae</em> and <em>Neisseria meningitidis</em> Vaccines on Immune Responses to Meningitis in Mouse Model" Preprints. https://doi.org/10.20944/preprints201701.0010.v1
Abstract
Meningitis is a severe disease associated with death in children under five with highest rates of infections under age of one. Vaccines for Neisseria meningitides and Haemophilus influenza are used to prevent the main causative agents of meningitis. Administration of H. influenzae type b (Hib) vaccine is recommended at 2, 4 and 6 months with a booster dose at 18 months. N. meningitidis has two commercially available vaccines, the pure polysaccharide is recommended at 24 months meanwhile the protein-conjugated vaccines at 12 months. We sought in this study to examine if coadministering the vaccines for the two main meningitis causing bacteria might be synergistic as a preliminary step towards the possibility of shuffling immunization schedule. So, we coadministered Hib vaccine with commercially available vaccines either quadrate (ACWY) polysaccharide meningococcal (Men) or conjugated meningococcal (Nim) vaccines in Balb/C mice (n = 6/group) and compared to each vaccine administered separately and controls. Thirty-five days post immunization, we measured specific antibodies titers. Hib vaccine increased Men antibody titers significantly for serotypes Y and W. When Hib vaccine was coadministrated with Nim, antibody titer for Y, W and A significantly increased. For serotype C, there was no significant difference in antibody titers among immunized groups. As for effect of meningococcal vaccines on Hib, Men significantly increased Hib antibody titers while Nim had no effect. Collectively, our data suggested that coadministration of Hib and Men or Nim vaccines was safe and had synergistic effect on immune responses elicited to both vaccines. Further studies are needed before immunization schedule modifications. Such immunization schedule recommendation should provide better protection against this life-threatening disease in young children.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
