PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Expression and Potential Function of Plasma Exosomal microRNAs (miR-483-5p, miR-671-5p, and miR-150-3p) in a Mouse Mode and in Mesial Temporal Lobe Epilepsy Patients
Version 1
: Received: 30 December 2016 / Approved: 30 December 2016 / Online: 30 December 2016 (07:43:42 CET)
How to cite:
Yan, S.; Liu, G.; Xie, W.; Meng, D.; Zhang, H.; Meng, F.; Zhang, K.; Jiang, Y.; Zhang, X.; Zhang, J. Expression and Potential Function of Plasma Exosomal microRNAs (miR-483-5p, miR-671-5p, and miR-150-3p) in a Mouse Mode and in Mesial Temporal Lobe Epilepsy Patients. Preprints2016, 2016120151. https://doi.org/10.20944/preprints201612.0151.v1
Yan, S.; Liu, G.; Xie, W.; Meng, D.; Zhang, H.; Meng, F.; Zhang, K.; Jiang, Y.; Zhang, X.; Zhang, J. Expression and Potential Function of Plasma Exosomal microRNAs (miR-483-5p, miR-671-5p, and miR-150-3p) in a Mouse Mode and in Mesial Temporal Lobe Epilepsy Patients. Preprints 2016, 2016120151. https://doi.org/10.20944/preprints201612.0151.v1
Yan, S.; Liu, G.; Xie, W.; Meng, D.; Zhang, H.; Meng, F.; Zhang, K.; Jiang, Y.; Zhang, X.; Zhang, J. Expression and Potential Function of Plasma Exosomal microRNAs (miR-483-5p, miR-671-5p, and miR-150-3p) in a Mouse Mode and in Mesial Temporal Lobe Epilepsy Patients. Preprints2016, 2016120151. https://doi.org/10.20944/preprints201612.0151.v1
APA Style
Yan, S., Liu, G., Xie, W., Meng, D., Zhang, H., Meng, F., Zhang, K., Jiang, Y., Zhang, X., & Zhang, J. (2016). Expression and Potential Function of Plasma Exosomal microRNAs (miR-483-5p, miR-671-5p, and miR-150-3p) in a Mouse Mode and in Mesial Temporal Lobe Epilepsy Patients. Preprints. https://doi.org/10.20944/preprints201612.0151.v1
Chicago/Turabian Style
Yan, S., Xin Zhang and Jianguo Zhang. 2016 "Expression and Potential Function of Plasma Exosomal microRNAs (miR-483-5p, miR-671-5p, and miR-150-3p) in a Mouse Mode and in Mesial Temporal Lobe Epilepsy Patients" Preprints. https://doi.org/10.20944/preprints201612.0151.v1
Abstract
Mesial temporal lobe epilepsy (mTLE) is one of the most common and refractory focal epilepsy syndromes. The molecular mechanisms of TLE are not completely understood. The aim of this study was to investigate the expression and potential function of plasma exosomal miRNAs (miR-483-5p, miR-671-5p, and miR-150-3p) in a mouse mode and in temporal lobe epilepsy patients. It was found that exosomal miRNAs were differentially expressed in three phases of the mouse mode, and exosomal miRNAs were down-regulated in mTLE patients compared with healthy controls. A bioinformatics analysis showed that target genes of exosomal miRNAs were significantly involved in the apoptotic process, cell adhesion, nervous system development, neurotrophin signaling pathway, PI3K-Akt signaling pathway, and metabolic pathways. The areas under the curve of miR-483-5p and miR-150-3p were 0.8714 (sensitivity = 75.00%, specificity = 91.65%) and 0.8213 (sensitivity = 67.50%, specificity = 90.00%), respectively. More importantly, the exosomal miRNAs were significantly associated with clinical parameters. Exosomal miRNAs may have the potential to become diagnostic and therapeutic biomarkers.
Keywords
epilepsy; exosoma; microRNA
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
