Preprint Article Version 1 NOT YET PEER-REVIEWED

Influence of Gender on CMV Seropositivity in Non-A To G Hepatitis Virus Patients

1
Assistant Prof of Virology and molecular microbiology, Health science Researches central, Princes Nora University (PNU), Kingdom Saudi Arabia (KSA)
2
Prof of Genetic, Biology department, Princes Nora University (PNU), Kingdom Saudi Arabia (KSA)
3
Assistant Prof of molecular biology, Biology department, Princes Nora University (PNU), Kingdom Saudi Arabia (KSA)
4
Prof Biochemistry, Central Labe, King Saud University (KSU)
Version 1 : Received: 6 November 2016 / Approved: 5 December 2016 / Online: 5 December 2016 (11:08:57 CET)

How to cite: Farag, R.; Alayobi, D.; Kwon, H.; Elansary, A. Influence of Gender on CMV Seropositivity in Non-A To G Hepatitis Virus Patients. Preprints 2016, 2016120026 (doi: 10.20944/preprints201612.0026.v1). Farag, R.; Alayobi, D.; Kwon, H.; Elansary, A. Influence of Gender on CMV Seropositivity in Non-A To G Hepatitis Virus Patients. Preprints 2016, 2016120026 (doi: 10.20944/preprints201612.0026.v1).

Abstract

Background Cytomegalovirus (CMV) is a major pathogen that cause remarkable rate of morbidity and mortality, especially in immunocompromised patients. It is important to find risk factors associated with CMV viremia. We studied the differences in CMV seropositivity in relation to liver function biomarkers in male and female Saudi population in an attempt to understand the variation in the CMV seroprevalence with sex and find the risk factor to develop liver dysfunction or hepatocellular carcinoma. Material and subjects: The CMV- IgG and IgM were screened in serum samples of 150 non- A-G hepatities patients with elevation of liver profiles (ALT, AST, ALP and GGT) and categorized as males and females. Samples were collected from different general hospitals and polyclinic in KSA from March 2014 to June 2015. A correlation between CMV seropositivity measured with both antibodies and liver enzymes were tested. Receiver operating characteristics (ROC) analysis and multiple regressions were done for the obtained data. Results: Our study shows that females had much higher IgG and IgM compared to age-matching males. A significant correlation between both antibodies and liver enzymes (AST, ALT) was recorded. Less significant correlation of both IgG and IgM with GGT was also observed. Receiver operating characteristics (ROC) analysis revealed that both IgG and IgM can be used as excellent predictive markers for CMV infection as both recorded 100% specificity and sensitivity together with area under the curve of 1 in males and females. Multiple regression analysis ascertain the correlation between both antibodies as dependent variables and liver enzymes as independent variables with ALT being the most affected enzyme with CMV seropositivity especially in females. Conclusion:he data discussed above This study shows that CMV is capable of initiating and accelerating liver dysfunction in both sexes. The high seroprevalence in females at reproductive age is especially important as they can transmit the virus to their developing fetus. Prevention of CMV infection in young girls 11-14 years old, through counseling on hygiene or possible future vaccination, may lead to a decrease of congenital CMV infections with the concomitant risk of developing liver dysfunction or hepatocellular carcinoma. Keywords: Cytomegalovirus, Alanine transaminase, Aspartate transaminase Alkaline phosphatase, γ-Glutamyltranspeptidase, liver function.

Subject Areas

cytomegalovirus; alanine transaminase; aspartate transaminase alkaline phosphatase; γ-glutamyltranspeptidase; liver function

Readers' Comments and Ratings (3)

Importance: How significant is the paper to the field?
Outstanding/highlight paper
50%
Significant contribution
50%
Incremental contribution
0%
No contribution
0%
Soundness of evidence/arguments presented:
Conclusions well supported
100%
Most conclusions supported (minor revision needed)
0%
Incomplete evidence (major revision needed)
0%
Hypothesis, unsupported conclusions, or proof-of-principle
0%
Comment 1
Received: 5 December 2016
Commenter: ahmed abdel moniem ahmed mostafa
Commenter's Affiliation: cairo university
The commenter has declared there is no conflict of interests.
Comment:
+ Respond to this comment
Comment 2
Received: 5 December 2016
Commenter: Mashael Al-Anazi
Commenter's Affiliation: King Faisal Specialist Hospital and Research Center
The commenter has declared there is no conflict of interests.
Comment: Significant contribution
Conclusions well supported
+ Respond to this comment
Comment 3
Received: 6 December 2016
Commenter: Tarek Abdul Majeed Hassan
Commenter's Affiliation: Alex University
The commenter has declared there is no conflict of interests.
Comment: Outstanding/highlight paper
Conclusions well supported
+ Respond to this comment
Discuss and rate this article
Views 292
Downloads 92
Comments 3
Metrics 0
Discuss and rate this article

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.