3D Printing of Cytocompatible Water-Based Light-Cured Polyurethane with Hyaluronic Acid for Cartilage Tissue Engineering Applications

Ming-You Shie; Wen-Ching Chang; Li-Ju Wei; Yu-Hsin Huang; Chien-Han Chen; Yi-Wen Chen; Yu-Fang Shen

doi:10.20944/preprints201611.0150.v1

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preprints.org > chemistry and materials science > biomaterials > doi: 10.20944/preprints201611.0150.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

3D Printing of Cytocompatible Water-Based Light-Cured Polyurethane with Hyaluronic Acid for Cartilage Tissue Engineering Applications

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Version 1 : Received: 30 November 2016 / Approved: 30 November 2016 / Online: 30 November 2016 (04:28:15 CET)

A peer-reviewed article of this Preprint also exists.

Shie, M.-Y.; Chang, W.-C.; Wei, L.-J.; Huang, Y.-H.; Chen, C.-H.; Shih, C.-T.; Chen, Y.-W.; Shen, Y.-F. 3D Printing of Cytocompatible Water-Based Light-Cured Polyurethane with Hyaluronic Acid for Cartilage Tissue Engineering Applications. Materials 2017, 10, 136. Shie, M.-Y.; Chang, W.-C.; Wei, L.-J.; Huang, Y.-H.; Chen, C.-H.; Shih, C.-T.; Chen, Y.-W.; Shen, Y.-F. 3D Printing of Cytocompatible Water-Based Light-Cured Polyurethane with Hyaluronic Acid for Cartilage Tissue Engineering Applications. Materials 2017, 10, 136.

Abstract

Diseases in articular cartilages have affected millions of people globally. Although the biochemical and cellular composition of articular cartilages is relatively simple, there is the limitation in self-repair ability of cartilage. Therefore, developing the strategies for cartilage repair is very important. Here, we reported a new manufacturing process of water-based polyurethane based photosensitive materials with hyaluronic acid and applied the materials for 3D printed customized cartilage scaffolds. The scaffold has high cytocompatibility and is one that closely mimics the mechanical properties of articular cartilages. It is suitable for culturing human Wharton's jelly mesenchymal stem cells (hWJMSCs) and the cells showed an excellent chondrogenic differentiation capacity. We consider that the 3D printing hybrid scaffolds may have potential in customized tissue engineering and facilitate the development of cartilage tissue engineering.

Keywords

water-based polyurethane; hyaluronic acid; cartilage tissue engineering; scaffold

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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