Preprint Article Version 1 NOT YET PEER-REVIEWED

Changes in Biochemical Parameters of the Calcium-Phosphorus Homeostasis in Relation to Nutritional Intake in Very-Low-Birth-Weight Infants

  1. Department of Paediatrics, Subdivision of Neonatology, Radboudumc Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen 6525 GA, The Netherlands
  2. Department for Health Evidence, Radboud Institute for Health Science, Radboud University Medical Center, Nijmegen 6525 GA, The Netherlands
  3. Department of Paediatrics, Radboudumc Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen 6525 GA, The Netherlands
  4. Department of Paediatrics, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
  5. Department of Paediatrics, Emma Children’s Hospital - AMC, 1105 AZ Amsterdam, The Netherlands
Version 1 : Received: 24 November 2016 / Approved: 25 November 2016 / Online: 25 November 2016 (10:14:30 CET)

A peer-reviewed article of this Preprint also exists.

Christmann, V.; Gradussen, C.J.W.; Körnmann, M.N.; Roeleveld, N.; van Goudoever, J.B.; van Heijst, A.F.J. Changes in Biochemical Parameters of the Calcium-Phosphorus Homeostasis in Relation to Nutritional Intake in Very-Low-Birth-Weight Infants. Nutrients 2016, 8, 764. Christmann, V.; Gradussen, C.J.W.; Körnmann, M.N.; Roeleveld, N.; van Goudoever, J.B.; van Heijst, A.F.J. Changes in Biochemical Parameters of the Calcium-Phosphorus Homeostasis in Relation to Nutritional Intake in Very-Low-Birth-Weight Infants. Nutrients 2016, 8, 764.

Journal reference: Nutrients 2016, 8, 764
DOI: 10.3390/nu8120764

Abstract

Preterm infants are at significant risk to develop reduced bone mineralization based on inadequate supply of calcium and phosphorus (Ca-P). Biochemical parameters can be used to evaluate the nutritional intake. The direct effect of nutritional intake on changes in biochemical parameters has not been studied. Our objective was to evaluate the effect of Ca-P supplementation on biochemical markers as serum (s)/urinary (u) Ca and P; alkaline phosphatase (ALP); tubular reabsorption of P (TrP) and urinary ratios for Ca/creatinin and P/creatinin in Very-Low-Birth-Weight infants on postnatal day 1, 3, 5, 7, 10, and 14. This observational study compared two groups with High (n = 30) and Low (n = 40) intake of Ca-P. Birth weight: median (IRQ) 948 (772-1225) vs. 939 (776-1163) grams; Gestational age: 28.2 (26.5-29.6) vs. 27.8 (26.1-29.4) weeks. Daily median concentrations of biochemical parameter were not different between the groups but linear regression mixed model analyses showed that Ca intake increased the uCa and TrP (p = 0.04) and decreased ALP (p = 0.00). Phosphorus intake increased sP, uP and uP/creat ratio and ALP (p ≤ 0.02) and caused decrease in TrP (p = 0.00). Protein intake decreased sP (p = 0.000), while low gestational age and male gender increased renal excretion of P (p < 0.03). Standardized repeated measurements showed that biochemical parameters were affected by nutritional intake, gestational age and gender.

Subject Areas

blood; bone mineralization; minerals; monitoring; nutrition; renal tubular reabsorption; supplementation; urine

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