Preprint Article Version 1 NOT YET PEER-REVIEWED

Effect of Anti Diabetic Drugs on Lipid Profile in Patients with Type 2 Diabetes Mellitus

  1. Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq
  2. Department of Chemistry, College of Science, University of Al-Mustansiriyah, Baghdad, Iraq
  3. Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Nahrain University, Baghdad, Iraq
  4. Medical Technology Department, Faculty of Medical Technology, Misurata, Libya
  5. Environmental Research Center, University of Technology, Baghdad, Iraq
Version 1 : Received: 2 November 2016 / Approved: 14 November 2016 / Online: 14 November 2016 (07:14:00 CET)

How to cite: Jawad, A.; Al-Qaisi, Z.; Ibrahim, A.; Hallab, Z.; Graisa, A.; Al-Amiery, A.; Yousif, E. Effect of Anti Diabetic Drugs on Lipid Profile in Patients with Type 2 Diabetes Mellitus. Preprints 2016, 2016110071 (doi: 10.20944/preprints201611.0071.v1). Jawad, A.; Al-Qaisi, Z.; Ibrahim, A.; Hallab, Z.; Graisa, A.; Al-Amiery, A.; Yousif, E. Effect of Anti Diabetic Drugs on Lipid Profile in Patients with Type 2 Diabetes Mellitus. Preprints 2016, 2016110071 (doi: 10.20944/preprints201611.0071.v1).

Abstract

Diabetes mellitus (DM) has been defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. This study includes (84) subjects, their age ranged from (40 to 54) years. (20) subjects were healthy chosen as control group and (64) patients with type 2 diabetes mellitus were divided into three groups according to their type of anti diabetic therapy: (23) newly diagnosed group without therapy (Group1), (20) with metformin therapy (Group2) and (21) with metformin plus glibenclamide therapies (Group3). In the study lipid profile level were quantitatively determine by enzymatic methods, in addition to that fasting plasma glucose (FPG), Glycated hemoglobin (HbA1c%) and body mass index (BMI) were identified in the patients. There is significant increase in the level of lipid profile in patients group. Metformin alone produce a non-significant favorable effect on all lipids profile parameters while metformin plus glibenclamide showed a significant reduction in TC and LDL-C.

Subject Areas

diabetes mellitus; metformin; glibenclamide and lipid profile

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