Preprint Review Version 1 NOT YET PEER-REVIEWED

Review on Usage of Vancomycin in Livestock and Humans: Maintaining its Efficacy, Prevention of Resistance and Alternative Therapy

  1. Veterinary Surgeon and Senior Assistant Secretary, University Grants Commission, Ward Pl, Colombo 00700, Sri Lanka
  2. Department of Biochemistry, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Mihintale, Sri Lanka
  3. Department of Microbiology, Faculty of Medicine and Allied Sciences, Rajarata University, Mihintale, Sri Lanka
  4. Department of Chemistry, University of Delhi, Delhi 110007, India
Version 1 : Received: 12 November 2016 / Approved: 12 November 2016 / Online: 12 November 2016 (11:09:37 CET)

How to cite: WIJESEKARA, P.; Kumbukgolla, W.; Jayaweera, J.; Rawat, D. Review on Usage of Vancomycin in Livestock and Humans: Maintaining its Efficacy, Prevention of Resistance and Alternative Therapy. Preprints 2016, 2016110067 (doi: 10.20944/preprints201611.0067.v1). WIJESEKARA, P.; Kumbukgolla, W.; Jayaweera, J.; Rawat, D. Review on Usage of Vancomycin in Livestock and Humans: Maintaining its Efficacy, Prevention of Resistance and Alternative Therapy. Preprints 2016, 2016110067 (doi: 10.20944/preprints201611.0067.v1).

Abstract

Vancomycin is one of the ‘last-line’ classes of antibiotics used in the treatment of life-threatening infections caused by Gram-positive bacteria. Even though vancomycin was discovered in 1950s it was widely used after 1980s for the treatment of infections caused by methicillin-resistant Staphylococci as prevalence of such strains were increased. However, currently it is evident that vancomycin resistant Staphylococcusaureusandvancomycin-resistant Enterococci have been developed as a result of various reasons including use of avaparcin, which is an analog of vancomycin, as feed additive in livestock. In present day context, more attention should be paid on prevention of emergence of resistance for the antibiotics in order to keep antibiotics effective. In order to prevent emergence of resistance, proper guidance for the responsible use of antimicrobials is indispensable. Therefore, almost all stakeholders who use antibiotics should have in depth understanding on the antibiotic they use. As such, it is imperative to be aware of the important aspects of vancomycin. In the present review, efforts have been made to discussthe pharmacokinetics and pharmacodynamics, indications, emergence of resistance, control of resistance, adverse effects and alternative therapy for vancomycin.

Subject Areas

vancomycin; broad view; veterinary use at a glance; rational use; alternatives

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