Version 1
: Received: 7 November 2016 / Approved: 8 November 2016 / Online: 8 November 2016 (10:40:34 CET)
How to cite:
Chowdhury, R.; Taneja, S.; Bhandari, N.; Sinha, B.; Upadhyay, R.; Bhan, M.K.; Strand, T.A. Vitamin-D Deficiency Predicts Infections in Young North Indian Children: A Secondary Data Analysis. Preprints2016, 2016110049. https://doi.org/10.20944/preprints201611.0049.v1
Chowdhury, R.; Taneja, S.; Bhandari, N.; Sinha, B.; Upadhyay, R.; Bhan, M.K.; Strand, T.A. Vitamin-D Deficiency Predicts Infections in Young North Indian Children: A Secondary Data Analysis. Preprints 2016, 2016110049. https://doi.org/10.20944/preprints201611.0049.v1
Chowdhury, R.; Taneja, S.; Bhandari, N.; Sinha, B.; Upadhyay, R.; Bhan, M.K.; Strand, T.A. Vitamin-D Deficiency Predicts Infections in Young North Indian Children: A Secondary Data Analysis. Preprints2016, 2016110049. https://doi.org/10.20944/preprints201611.0049.v1
APA Style
Chowdhury, R., Taneja, S., Bhandari, N., Sinha, B., Upadhyay, R., Bhan, M.K., & Strand, T.A. (2016). Vitamin-D Deficiency Predicts Infections in Young North Indian Children: A Secondary Data Analysis. Preprints. https://doi.org/10.20944/preprints201611.0049.v1
Chicago/Turabian Style
Chowdhury, R., Maharaj Kishan Bhan and Tor A. Strand. 2016 "Vitamin-D Deficiency Predicts Infections in Young North Indian Children: A Secondary Data Analysis" Preprints. https://doi.org/10.20944/preprints201611.0049.v1
Abstract
Recent studies have demonstrated a relationship between poor vitamin D status and respiratory infections and diarrhea among young children. Acute lower respiratory infections (ALRI) and diarrhea are among the two most important causes of death in under-5 children. In this analysis, we examine the extent to which vitamin-D deficiency (<10 ng/ml) predicts these outcomes using data from a randomized controlled trial (RCT) of daily folic acid and/ or vitamin B12 supplementation for six months in 6 to 30 months old children conducted in Delhi, India. Of the 960 subjects who had vitamin-D concentrations measured, 331(34.5%) were vitamin-D deficient. We found, after controlling for relevant potential confounders (age, sex, breastfeeding status, wasting, stunting, underweight, anemia status at base line and season), the risk of ALRI was significantly higher among vitamin-D deficient (OR 1.26; 95% CI: 1.03 to 1.55) compared to vitamin-D-replete children in the six months follow-up period. Vitamin-D status was not significantly associated with episodes of diarrhea and clinical pneumonia. The extent of causal relationship of vitamin-D status and ALRI needs to be explored in further studies.
Keywords
vitamin-D deficiency; ALRI; Indian children
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
