Preprint Article Version 1 NOT YET PEER-REVIEWED

Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance

  1. Laboratory of Natural Products and Organic Synthesis, Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Box: 812, Yaoundé, Cameroon
  2. Antimicrobial & Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé P.O. Box: 812, Yaoundé, Cameroon
  3. Chemistry Department, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, D-33501 Bielefeld, Germany
  4. Giresun University, Faculty of Engineering, Department of Industrial Engineering, 28200 Giresun, Turkey
  5. Agrı Ibrahim Cecen University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, 04100 Agri, Turkey
  6. Agrı Ibrahim Cecen University, School of Health, Department of Nutrition and Dietetics, 04100 Agri, Turkey
  7. Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Yaoundé, Cameroon
Version 1 : Received: 2 November 2016 / Approved: 3 November 2016 / Online: 3 November 2016 (09:35:17 CET)

How to cite: Tchuenmogne, M.; Ngouana, T.; Gohlke, S.; Kouipou, R.; Aslan, A.; Kuzu, M.; Comakli, V.; Demirdag, R.; Ngouela, S.; Tsamo, E.; Sewald, N.; Lenta, B.; Boyom, F. Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance. Preprints 2016, 2016110023 (doi: 10.20944/preprints201611.0023.v1). Tchuenmogne, M.; Ngouana, T.; Gohlke, S.; Kouipou, R.; Aslan, A.; Kuzu, M.; Comakli, V.; Demirdag, R.; Ngouela, S.; Tsamo, E.; Sewald, N.; Lenta, B.; Boyom, F. Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance. Preprints 2016, 2016110023 (doi: 10.20944/preprints201611.0023.v1).

Abstract

The chemical investigation of the anti-yeast methanol extract from the stem bark of Terminalia mantaly led to the isolation of seven compounds: 3-O-methyl-4-O-α-rhamnopyranoside ellagic acid (1), 3-O-mehylellagic acid (2), arjungenin or 2,3,19,23-tetrahydroxyolean-12-en-28-oïc acid (3), arjunglucoside or 2,3,19,23-tetrahydroxyolean-12-en-28-oïc acid glucopyranoside (4), 2α,3α,24-trihydroxyolean-11,13(18)-dien-28-oïc acid (5), stigmasterol (6), stigmasterol 3-O-β-D-glucopyranoside (7). Their structures were established by means of spectroscopic analysis and comparison with published data. Compounds 1-5 were tested in vitro for activity against three pathogenic yeast isolates, Candida albicans, Candida parapsilosis and Candida krusei. The activity of compounds 1, 2 and 4 were comparable to that of the reference compound fluconazole (MIC values below 32 µg/ml) against the three tested yeast isolates. They were also tested for inhibitory properties against four enzymes of metabolic significance: Glucose-6-Phosphate Deshydrogenase (G6PD), human erythrocyte Carbonic anhydrase I and II (hCA I and hCA II), Glutathione S-transferase (GST). Compound 4 showed highly potent inhibitory property against the four tested enzymes with overall IC50 values below 4 µM and inhibitory constant (Ki) <3 µM.

Subject Areas

anti-yeast; enzyme inhibitors; Terminalia mantaly; Combretaceae

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