Preprint Article Version 1 NOT YET PEER-REVIEWED

Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance

1
Laboratory of Natural Products and Organic Synthesis, Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Box: 812, Yaoundé, Cameroon
2
Antimicrobial & Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé P.O. Box: 812, Yaoundé, Cameroon
3
Chemistry Department, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, D-33501 Bielefeld, Germany
4
Giresun University, Faculty of Engineering, Department of Industrial Engineering, 28200 Giresun, Turkey
5
Agrı Ibrahim Cecen University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, 04100 Agri, Turkey
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Agrı Ibrahim Cecen University, School of Health, Department of Nutrition and Dietetics, 04100 Agri, Turkey
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Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Yaoundé, Cameroon
Version 1 : Received: 2 November 2016 / Approved: 3 November 2016 / Online: 3 November 2016 (09:35:17 CET)

How to cite: Tchuenmogne, M.; Ngouana, T.; Gohlke, S.; Kouipou, R.; Aslan, A.; Kuzu, M.; Comakli, V.; Demirdag, R.; Ngouela, S.; Tsamo, E.; Sewald, N.; Lenta, B.; Boyom, F. Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance. Preprints 2016, 2016110023 (doi: 10.20944/preprints201611.0023.v1). Tchuenmogne, M.; Ngouana, T.; Gohlke, S.; Kouipou, R.; Aslan, A.; Kuzu, M.; Comakli, V.; Demirdag, R.; Ngouela, S.; Tsamo, E.; Sewald, N.; Lenta, B.; Boyom, F. Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against some Pathogenic Yeasts and Enzymes of Metabolic Significance. Preprints 2016, 2016110023 (doi: 10.20944/preprints201611.0023.v1).

Abstract

The chemical investigation of the anti-yeast methanol extract from the stem bark of Terminalia mantaly led to the isolation of seven compounds: 3-O-methyl-4-O-α-rhamnopyranoside ellagic acid (1), 3-O-mehylellagic acid (2), arjungenin or 2,3,19,23-tetrahydroxyolean-12-en-28-oïc acid (3), arjunglucoside or 2,3,19,23-tetrahydroxyolean-12-en-28-oïc acid glucopyranoside (4), 2α,3α,24-trihydroxyolean-11,13(18)-dien-28-oïc acid (5), stigmasterol (6), stigmasterol 3-O-β-D-glucopyranoside (7). Their structures were established by means of spectroscopic analysis and comparison with published data. Compounds 1-5 were tested in vitro for activity against three pathogenic yeast isolates, Candida albicans, Candida parapsilosis and Candida krusei. The activity of compounds 1, 2 and 4 were comparable to that of the reference compound fluconazole (MIC values below 32 µg/ml) against the three tested yeast isolates. They were also tested for inhibitory properties against four enzymes of metabolic significance: Glucose-6-Phosphate Deshydrogenase (G6PD), human erythrocyte Carbonic anhydrase I and II (hCA I and hCA II), Glutathione S-transferase (GST). Compound 4 showed highly potent inhibitory property against the four tested enzymes with overall IC50 values below 4 µM and inhibitory constant (Ki) <3 µM.

Subject Areas

anti-yeast; enzyme inhibitors; Terminalia mantaly; Combretaceae

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