Preprint Communication Version 1 NOT YET PEER-REVIEWED

A Validated HPLC Method for the Determination of Vanillyl Butyl Ether in Cosmetic Preparations

  1. Suavizantes y plastificantes Bituminosos S.L. Poligono Industrial de Cheste, vial 6. 46380, cheste, Valencia, España
Version 1 : Received: 24 October 2016 / Approved: 25 October 2016 / Online: 25 October 2016 (09:43:18 CEST)

How to cite: Alberola, A.; Trigo, F.; Melendez, J.; Muedra, G. A Validated HPLC Method for the Determination of Vanillyl Butyl Ether in Cosmetic Preparations. Preprints 2016, 2016100106 (doi: 10.20944/preprints201610.0106.v1). Alberola, A.; Trigo, F.; Melendez, J.; Muedra, G. A Validated HPLC Method for the Determination of Vanillyl Butyl Ether in Cosmetic Preparations. Preprints 2016, 2016100106 (doi: 10.20944/preprints201610.0106.v1).

Abstract

A specific HPLC method has been developed and validated for the determination of vanillyl butyl ether in cosmetic products. The extraction procedure with an isopropanol water 1:1 mixture is described. The method uses a RP-C-18 column with isocratic elution and a UV detector. The mobile phase consists of a mixture of acetonitrile and buffer (Na2HPO4 20mM in water) (30:70 v/v) with a variable flow rate. The method was validated with respect to accuracy, precision (repeatability and reproducibility), specificity and linearity. The procedure described here is simple, selective and reliable for routine quality control analysis and stability tests of commercially available cosmetic products.

Subject Areas

vanillyl butyl ether; HPLC; method validation; cosmetic product

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