Preprint Article Version 1 NOT YET PEER-REVIEWED

Impact of Soft Tissue Pathophysiology in the Development and Maintenance of Bisphosphonate Related Osteonecrosis of the Jaw (BRONJ)

  1. Department of Maxillofacial Surgery, University Hospital, Baldingerstraße, D-35043 Marburg, Germany
  2. Department of Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, D-55131 Mainz, Germany
  3. Oral and Maxillofacial Surgery, Mediplus Clinic, Haifa-Allee 20, D-55128 Mainz, Germany
Version 1 : Received: 14 October 2016 / Approved: 15 October 2016 / Online: 15 October 2016 (08:03:48 CEST)

A peer-reviewed article of this Preprint also exists.

Ziebart, T.; Halling, F.; Heymann, P.; Neff, A.; Blatt, S.; Jung, J.; Pabst, A.; Righesso, L.; Walter, C. Impact of Soft Tissue Pathophysiology in the Development and Maintenance of Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ). Dent. J. 2016, 4, 36. Ziebart, T.; Halling, F.; Heymann, P.; Neff, A.; Blatt, S.; Jung, J.; Pabst, A.; Righesso, L.; Walter, C. Impact of Soft Tissue Pathophysiology in the Development and Maintenance of Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ). Dent. J. 2016, 4, 36.

Journal reference: Dent. J. 2016, 4, 36
DOI: 10.3390/dj4040036

Abstract

Since the first description of bisphosphonate-related osteonecrosis of the jaw (BRONJ) numerous research groups have focused on possible pathological mechanisms including the suppression of the bone turnover of the jaw, antiangiogenic effects and soft tissue toxicity. In our review we focused on summarizing the role of the soft tissues in the development and progression of BRONJ. The biological behavior of fibroblasts can be significantly influenced by bisphosphonates (BP) such as a concentration dependent reduction of cell viability. High concentrations of BP can induce apoptosis and necrosis of the cells. Comparable effects could be detected for keratinocytes. Compared to non-nitrogen containing bisphosphonates nitrogen-containing BP have worse effects on cell biology by blocking the mevalonate pathway. Next to this the cell architecture and the expression levels of several genes and proteins are significantly disturbed by BP. These inhibitory effects of BP are in accordance with BP related reduced angiogenesis and neovascularization and could underline the hypothesis that inhibition of fibroblasts and keratinocytes results in delayed wound healing and can induce and trigger BRONJ.

Subject Areas

gingiva; bisphosphonate; soft tissue; fibroblasts; keratinocytes; bisphosphonate associated osteonecrosis of the jaws

Readers' Comments and Ratings (0)

Discuss and rate this article
Views 72
Downloads 72
Comments 0
Metrics 0
Discuss and rate this article

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.