Pharmaceutics Research Group, School of Pharmacy, Bandung Institute of Technology, Bandung 40132, Indonesia
Research Center for Nanosciences and Nanotechnology, Bandung Institute of Technology, Bandung 40132, Indonesia
Biopharmaceutics & NutriCosmetics, Pharmaceutical Technology, Department of Pharmacy, Freie Universität Berlin, Berlin 14195, Germany
: Received: 26 September 2016 / Approved: 26 September 2016 / Online: 26 September 2016 (11:47:18 CEST)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
How to cite:
Rachmawati, H.; Rahma, A.; Shaal, L.; Müller, R.; Keck, C. Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolyte. Preprints2016, 2016090094 (doi: 10.20944/preprints201609.0094.v1).
Rachmawati, H.; Rahma, A.; Shaal, L.; Müller, R.; Keck, C. Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolyte. Preprints 2016, 2016090094 (doi: 10.20944/preprints201609.0094.v1).
Journal reference: Scientia Pharmaceutica 2016, 84, 685 DOI: 10.3390/scipharm84040685
We have successfully developed curcumin nanosuspension aimed for oral delivery. The main purpose is to improve bioavailability through enhancing its solubility. The nanoparticles were stabilized using various stabilizers including polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), sodium carboxymethylcellulose (Na-CMC), d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), and sodium dodecyl sulfate (SDS). The average diameter of particles, microscopic appearance, and sedimentation of each preparation was observed and compared. Each stabilizer demonstrated different degree of inhibition of particle aggregation under electrolyte-containing simulated gastrointestinal (GIT) fluid. Non-ionic stabilizers (PVA, PVP, and TPGS) has shown to preserve the nanosuspension stability against electrolytes. In contrast, strong ionic surfactants such as SDS were found to be very sensitive to electrolytes. The results can provide useful information for the formulators to choose the most suitable stabilizers by considering the nature of stabilizers and physiological characteristics of target site of the drug.