Preprint Article Version 1 NOT YET PEER-REVIEWED

Effects of Fetal Exposure to Asian Sand Dust on Fetal Development and Reproductive Function in Male Offspring

  1. Department of Health and Sciences, Oita University of Nursing and Health Sciences, Oita 870-1201, Japan
  2. Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Fukuoka 807-8555, Japan
  3. Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, Shenyang 110122, China
  4. Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan
  5. Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
Version 1 : Received: 20 September 2016 / Approved: 20 September 2016 / Online: 20 September 2016 (11:39:47 CEST)

A peer-reviewed article of this Preprint also exists.

Yoshida, S.; Ichinose, T.; Arashidani, K.; He, M.; Takano, H.; Shibamoto, T. Effects of Fetal Exposure to Asian Sand Dust on Development and Reproduction in Male Offspring. Int. J. Environ. Res. Public Health 2016, 13, 1173. Yoshida, S.; Ichinose, T.; Arashidani, K.; He, M.; Takano, H.; Shibamoto, T. Effects of Fetal Exposure to Asian Sand Dust on Development and Reproduction in Male Offspring. Int. J. Environ. Res. Public Health 2016, 13, 1173.

Journal reference: Int. J. Environ. Res. Public Health 2016, 13, 1173
DOI: 10.3390/ijerph13111173

Abstract

In recent experimental studies, we reported the aggravating effects of Asian sand dust (ASD) on male reproductive function in mice. However, the effects of fetal ASD exposure on male reproductive function have not been investigated. The present study investigated the effects of fetal ASD exposure on reproductive function in male offspring. Using pregnant CD-1 mice, ASD was administered intratracheally on days 7 and 14 of gestation, and the reproductive function of male offspring was determined at 5, 10, and 15 weeks after birth. The secondary sex ratio was significantly lower in the fetal ASD-exposed mice than in the controls. Histologic examination showed partial vacuolation of seminiferous tubules in immature mice. Moreover, daily sperm production (DSP) was significantly less in the fetal ASD-exposed mice than in the controls. DSP in the fetal ASD-exposed mice was approximately 10% less than the controls at both 5 and 10 weeks. However, both the histologic changes and the DSP decrease were reversed as the mice matured. These findings suggest that ASD exposure affects both the fetal development and the reproductive function of male offspring. In the future, it will be necessary to clarify the onset mechanisms of ASD-induced male fetus death and male reproductive disorders.

Subject Areas

asian sand dust; in utero exposure; secondary sex ratio; male reproduction; daily sperm production

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