Preprint Communication Version 1 NOT YET PEER-REVIEWED

Sweat Gland Biopsy: A Possible Early Diagnostic Tool in the Anderson-Fabry Disease

  1. Department of Dermatology, University of Palermo, via del Vespro 131, 90127 Palermo, Italy
Version 1 : Received: 29 August 2016 / Approved: 30 August 2016 / Online: 30 August 2016 (04:27:17 CEST)

How to cite: Pistone, G.; Caputo, V.; Fattore, D.; Tilotta, G.; Bongiorno, M. Sweat Gland Biopsy: A Possible Early Diagnostic Tool in the Anderson-Fabry Disease. Preprints 2016, 2016080228 (doi: 10.20944/preprints201608.0228.v1). Pistone, G.; Caputo, V.; Fattore, D.; Tilotta, G.; Bongiorno, M. Sweat Gland Biopsy: A Possible Early Diagnostic Tool in the Anderson-Fabry Disease. Preprints 2016, 2016080228 (doi: 10.20944/preprints201608.0228.v1).

Abstract

Anderson-Fabry disease is a rare X-linked lysosomal storage disorder caused by deficient or absent activity of the enzyme alfa-galactosidase A. This defect enzyme leads to accumulation of glycolipids, primarily globotriaosylceramide (Gb3), in the vascular endothelium of several organs, including the skin, kidneys, nervous system, and heart. The characteristic early clinical features of Fabry disease include acroparaesthesia, angiokeratoma, heat intolerance, hypohidrosis, cornea verticillata and gastrointestinal symptoms. Later complications occur with the disease progression and include progressive renal failure, hypertrofic cardiomyopathy, cerebrovascular disease and reduced life expectancy. Anderson Fabry disease is therefore a disabling and systemic disease which requires a timely diagnosis. The purpose of our study is to define sweat glands morphological abnormalities in children and adolescents with Fabry disease with minimal symptoms and in patients affected by variants of Fabry disease in which biopsy is essential, to establish a baseline morphological diagnosis of the disease before to undergo to kidney or endomyocardial biopsy or when the classical approach is not possible because of some complications, with minimal discomfort for patients.

Subject Areas

lysosomal diseases; diagnosis

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Received: 4 September 2016
Commenter: jitendra
Commenter's Affiliation: OU university
The commenter has declared there is no conflict of interests.
Comment: Wow, this tutorial goes at the top of my favorites list. Thank you so much,
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