Preprint Article Version 1 NOT YET PEER-REVIEWED

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

  1. State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China
Version 1 : Received: 27 August 2016 / Approved: 29 August 2016 / Online: 29 August 2016 (10:46:49 CEST)

A peer-reviewed article of this Preprint also exists.

Fan, D.; Zhu, G.-Y.; Li, T.; Jiang, Z.-H.; Bai, L.-P. Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii. Molecules 2016, 21, 1146. Fan, D.; Zhu, G.-Y.; Li, T.; Jiang, Z.-H.; Bai, L.-P. Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii. Molecules 2016, 21, 1146.

Journal reference: Molecules 2016, 21, 1146
DOI: 10.3390/molecules21091146

Abstract

Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3′-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM.

Subject Areas

Tripterygium regelii; dimacrolide sesquiterpene pyridine alkaloids; anti-inflammation

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