State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China
: Received: 27 August 2016 / Approved: 29 August 2016 / Online: 29 August 2016 (10:46:49 CEST)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
How to cite:
Fan, D.; Zhu, G.; Li, T.; Jiang, Z.; Bai, L. Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii. Preprints2016, 2016080221 (doi: 10.20944/preprints201608.0221.v1).
Fan, D.; Zhu, G.; Li, T.; Jiang, Z.; Bai, L. Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii. Preprints 2016, 2016080221 (doi: 10.20944/preprints201608.0221.v1).
Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3′-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM.