Version 1
: Received: 16 August 2016 / Approved: 17 August 2016 / Online: 17 August 2016 (10:51:56 CEST)
How to cite:
Cerit, L.; Kemal, H.; Günsel, A.; Uncu, M.; Cerit, Z.; Gülsen, K.; Duygu, H. Assessment of Vitamin B12 in Patients with Coronary Tortuosity. Preprints2016, 2016080164. https://doi.org/10.20944/preprints201608.0164.v1
Cerit, L.; Kemal, H.; Günsel, A.; Uncu, M.; Cerit, Z.; Gülsen, K.; Duygu, H. Assessment of Vitamin B12 in Patients with Coronary Tortuosity. Preprints 2016, 2016080164. https://doi.org/10.20944/preprints201608.0164.v1
Cerit, L.; Kemal, H.; Günsel, A.; Uncu, M.; Cerit, Z.; Gülsen, K.; Duygu, H. Assessment of Vitamin B12 in Patients with Coronary Tortuosity. Preprints2016, 2016080164. https://doi.org/10.20944/preprints201608.0164.v1
APA Style
Cerit, L., Kemal, H., Günsel, A., Uncu, M., Cerit, Z., Gülsen, K., & Duygu, H. (2016). Assessment of Vitamin B12 in Patients with Coronary Tortuosity. Preprints. https://doi.org/10.20944/preprints201608.0164.v1
Chicago/Turabian Style
Cerit, L., Kamil Gülsen and Hamza Duygu. 2016 "Assessment of Vitamin B12 in Patients with Coronary Tortuosity" Preprints. https://doi.org/10.20944/preprints201608.0164.v1
Abstract
Background: Vitamin B 12 deficiency has been implicated in endothelial dysfunction and cardiovascular disease via hyperhomocysteinemia. Coronary tortuosity (CorT) is a common coronary angiography finding. The etiology, clinical implication and long term prognosis are still not well clarified. This study was conducted with the aim to evaluate the relationship between CorT and vitamin B12. Subjects and Method: The medical records of consecutive patients, who underwent coronary angiography, were retrospectively reviewed. The study group consisted of 1624 patients. Taking into consideration the inclusion criteria, 212 patients with CorT and 210 patients with normal coronary angiographies (control group) were included in the study. Vitamin B12, other biochemical parameters, clinical and echocardiographic parameters, and CorT score were evaluated in all patients. CorT is defined as fixed 3 bends during both systole and diastole, with each bend ≥45 °. Results: Patients with CorT had higher prevalence of older, female gender, hypertension, current smoking. Vitamin B12 was significantly decreased in patient with CorT (134.7±47.8 vs 239.6±53.8 p<0.001). On multivariate analysis age, female gender, hypertension, diabetes mellitus and vitamin B12 were independent predictors for CorT (OR 1.56; 95% CI: 1.247–1.962; p < 0.001, OR 1.628; 95% CI: 1.376-2.048; p<0.001, OR 1.865; 95% CI: 1.387-2.695; p<0.001, OR 1.362; 95% CI: 1.184-1.726; p<0.001, OR 1.862; 95% CI: 1.486-2.674; p<0.001, respectively). Conclusion: In our study, we have founded a significant relationship between vitamin B12 deficiency and CorT.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
