Preprint Article Version 1 NOT YET PEER-REVIEWED

Assessment of in Vivo Oxidative Stress Biomarkers in Relation to Disease Progression and Cell Proliferation in Benign and Malignant Breast Diseases

  1. Department of Biophysics, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India
  2. Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi-221005, India
Version 1 : Received: 10 August 2016 / Approved: 10 August 2016 / Online: 10 August 2016 (16:49:20 CEST)

A peer-reviewed article of this Preprint also exists.

Karki, K.; Pande, D.; Negi, R.; Khanna, R.S.; Khanna, H. An Assessment of Oxidative Damage and Non-Enzymatic Antioxidants Status Alteration in Relation to Disease Progression in Breast Diseases. Med. Sci. 2016, 4, 17. Karki, K.; Pande, D.; Negi, R.; Khanna, R.S.; Khanna, H. An Assessment of Oxidative Damage and Non-Enzymatic Antioxidants Status Alteration in Relation to Disease Progression in Breast Diseases. Med. Sci. 2016, 4, 17.

Journal reference: Med. Sci. 2016, 4, 17
DOI: 10.3390/medsci4040017

Abstract

The present study was aimed to evaluate the levels of oxidative stress markers in breast diseases by measuring the 8-hydoxy-2-deoxyguanosine (8-OHdG), vitamin A, vitamin C, vitamin E and total antioxidant status (TAS) alterations in relation to cell proliferation activity and disease progression. Significant increases in the level of oxidative damage marker 8-OHdG and cell proliferation activity were observed in breast carcinoma patients in comparison to benign and normal controls, which were accompanied by significant decrease in non enzymatic antioxidants and TAS concentrations. 8-OHdG and cell proliferation level were negatively correlated with non enzymatic antioxidants viz., Vitamin A, Vitamin C, vitamin E level and total antioxidant activity. Altered levels of biomarkers of oxidative stress and cell proliferation activity amongst the malignant, benign and controls suggest a correlation of increased oxidative stress and cell proliferation activity in the progression of disease in breast carcinoma patients. Among the oxidative stress markers and cell proliferation index, decreased level of vitamin A, vitamin C, vitamin E, TAS and increased level of 8-OHdG, cell proliferation index emerged as best predicted biomarkers for subjects with malignancy and benign breast disease.

Subject Areas

8-OHdG (8-hydroxy- 2-deoxyguanosine), vitamin A, vitamin C, vitamin E, ROS (reactive oxygen species), TAS (total antioxidant status)

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