Preprint Article Version 2 NOT YET PEER-REVIEWED

Preparation and Biomimetic Covalent Surface Modification of Doped Cerium Oxide Nanoparticles: A Proof of Concept on Versatility of Surface Modification for Nanobiological Applications

  1. Physical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
  2. School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
Version 1 : Received: 9 August 2016 / Approved: 9 August 2016 / Online: 9 August 2016 (15:09:01 CEST)
Version 2 : Received: 10 August 2016 / Approved: 11 August 2016 / Online: 11 August 2016 (11:06:02 CEST)

How to cite: Nanda, H. Preparation and Biomimetic Covalent Surface Modification of Doped Cerium Oxide Nanoparticles: A Proof of Concept on Versatility of Surface Modification for Nanobiological Applications. Preprints 2016, 2016080103 (doi: 10.20944/preprints201608.0103.v2). Nanda, H. Preparation and Biomimetic Covalent Surface Modification of Doped Cerium Oxide Nanoparticles: A Proof of Concept on Versatility of Surface Modification for Nanobiological Applications. Preprints 2016, 2016080103 (doi: 10.20944/preprints201608.0103.v2).

Abstract

The covalent biomimetic surface modification of Cerium oxide nanoparticles (CNPs) using hydrophilic biocompatible (6-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl)triethoxysilane (MEEETES) has strongly demanded its investigation towards the versatility of surface modification. In this report, we have extended the concept of biomimetic surface modification to trivalent metal ion doped CNPs for the production of aqueous dispersible CNPs with differential Ce+3/Ce+4 ratio. MEEETES surface modified Samarium (Sm) doped CNPs (MEEETES-SmCNPs) were prepared using ammonia induced ethylene glycol assisted precipitation method and were characterized. The chemical interaction of MEEETES functional moieties with doped nanoparticle surface was studied using powerful 13C cross polarization magic angle sample spinning nuclear magnetic resonance spectroscopy and was compared with that of MEEETES modified CNPs. The results showed that the MEEETES functional moieties had covalent interaction with the surface of Sm doped CNPs which indicated that the covalent surface modification of CNPs using MEEETES should be versatile. The surface modification using MEEETES should also be extended to several other transition metal ion doped and co-doped CNPs for the production of aqueous dispersible redox altered CNPs for various nanobiological applications.

Subject Areas

cerium oxide nanoparticle; doped and co-doped; biomimetic; covalent surface modification; aqueous dispersible; nanobiological applications

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