Universidade Federal Rural da Amazônia, Postdoctoral Fellowship Cnpq, Belém 66077-830, Brazil
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, Utrecht 3584 CM, The Netherlands
: Received: 8 August 2016 / Approved: 9 August 2016 / Online: 9 August 2016 (11:38:04 CEST)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
How to cite:
Meneses, A.; Schneeberger, K.; Kruitwagen, H.; Penning, L.; Steenbeek, F.; Burgener, I.; Spee, B. Intestinal Organoids—Current and Future Applications. Preprints2016, 2016080090 (doi: 10.20944/preprints201608.0090.v1).
Meneses, A.; Schneeberger, K.; Kruitwagen, H.; Penning, L.; Steenbeek, F.; Burgener, I.; Spee, B. Intestinal Organoids—Current and Future Applications. Preprints 2016, 2016080090 (doi: 10.20944/preprints201608.0090.v1).
Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from various species, organs and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, current and future uses of this exciting new insight model to veterinary medicine field.