Preprint Article Version 1 NOT YET PEER-REVIEWED

Identification and Characterization of Two New Forced Degradation Products of Saikosaponin a under the Stress of Acid Hydrolytic Condition

Jun Li 1 , Qiang Xu 1 , Hua Jiang 1,*
  1. College of Chemistry and Pharmaceutical Engineering, Henan University of Science and Technology, Luoyang 471023, China
Version 1 : Received: 8 August 2016 / Approved: 9 August 2016 / Online: 9 August 2016 (11:32:29 CEST)

A peer-reviewed article of this Preprint also exists.

Li, J.; Xu, Q.; Jiang, H. Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions. Molecules 2016, 21, 1232. Li, J.; Xu, Q.; Jiang, H. Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions. Molecules 2016, 21, 1232.

Journal reference: Molecules 2016, 21, 1232
DOI: 10.3390/molecules21091232

Abstract

Saikosaponin (SS) a is a compound with various pharmacological properties and easily degraded into SSb1 and SSg in acid condition. In present work another two new degradation products of SSa formed under acid hydrolytic condition were detected and isolated by analytical and semi-preparative liquid chromatography technology, furthermore their structures were characterized as hydroxyl-saikosaponin a and SSb2 by spectral analysis, which is not only essential in stability-indicating method development and validation but also could be used as a worst case to assess the analytical method performance of SSa. Moreover their structural transformation pathways were also proposed.

Subject Areas

Acid hydrolysis; Degradation product; Saikosaponin a

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