Preprint Article Version 1 NOT YET PEER-REVIEWED

A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis

  1. Department of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, Italy
  2. Department of Experimental Medicine, University of Perugia, 06123 Perugia, Italy
  3. Department of Economics, University of Perugia, 06123 Perugia, Italy
Version 1 : Received: 6 August 2016 / Approved: 6 August 2016 / Online: 6 August 2016 (12:30:38 CEST)

A peer-reviewed article of this Preprint also exists.

Fabiani, R.; Minelli, L.; Bertarelli, G.; Bacci, S. A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis. Nutrients 2016, 8, 626. Fabiani, R.; Minelli, L.; Bertarelli, G.; Bacci, S. A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis. Nutrients 2016, 8, 626.

Journal reference: Nutrients 2016, 8, 626
DOI: 10.3390/nu8100626

Abstract

Dietary patterns were recently applied to examine the relationship between eating habits and prostate cancer (PC) risk. While the associations between PC risk with glycemic index and Mediterranean score have been reviewed, no meta-analysis is currently available on dietary patterns defined by “a posteriori” methods. Search was carried out (PubMed, Web of Science) to identify studies reporting the relationship between dietary patterns and PC risk. Relevant dietary patterns were selected and the risk estimated were calculated by a random-effect model. Multivariable-adjusted odds ratios (ORs) for a 1st-percentile increase in dietary pattern score were combined by a dose response meta-analysis. 12 observational studies were included in the meta-analysis which identified “Healthy pattern” and “Western pattern”. The Healthy pattern was not related to PC risk (OR=0.96; 95% CI: 0.88-1.04) while the Western pattern significantly increased it (OR=1.34; 95% CI: 1.08-1.65). In addition, a “Carbohydrate pattern”, identified in four articles, was positively associated with a higher PC risk (OR=1.64; 95% CI: 1.35-2.00). A significant linear trend between the Western (p=0.011) and the Carbohydrate (p=0.005) pattern and the increment of PC risk was observed. The small numbers of studies included suggest that further investigations are necessary to support these findings.

Subject Areas

dietary pattern; prostate cancer; systematic review; meta-analysis

Readers' Comments and Ratings (0)

Discuss and rate this article
Views 149
Downloads 204
Comments 0
Metrics 0
Discuss and rate this article

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.