Preprint Article Version 1 NOT YET PEER-REVIEWED

Prokaryotic gene-family size correlations

Department of Evolutionary and Environmental Biology, University of Haifa, City Zip code, Israel;
Version 1 : Received: 29 July 2016 / Approved: 29 July 2016 / Online: 29 July 2016 (16:24:29 CEST)

A peer-reviewed article of this Preprint also exists.

Carmi, G.; Bolshoy, A. Gene-Family Extension Measures and Correlations. Life 2016, 6, 30. Carmi, G.; Bolshoy, A. Gene-Family Extension Measures and Correlations. Life 2016, 6, 30.

Journal reference: Life 2016, 6, 30
DOI: 10.3390/life6030030


The existence of multiple copies of genes is a well-known phenomenon. A gene family is a set of sufficiently similar genes, formed by gene duplication. In earlier works conducted on limited number of completely sequenced and annotated genomes it was found that size of gene family and size of genome are positively correlated. Additionally, it was found that several atypical microbes deviated from the observed general trend. In this study, we reexamined these associations on a larger dataset consisting of 1484 prokaryotic genomes and using several ranking approaches. We applied ranking methods in such a way that genomes with lower number of paralogs would have lower rank. Until now only simple ranking methods were used; we applied the Kemeny optimal aggregation approach as well. Regression and correlation analysis were utilized in order to accurately quantify and characterize the relationships between measures of paralog indices and genome size. In addition, boxplot analysis was employed as a method for outlier detection. We found that, in general, all paralog indexes positively correlate with an increase of genome size. As expected, different groups of atypical prokaryotic genomes were found for different types of paralog quantities.

Subject Areas

number of paralogs; comparative genomics; combinatorial optimization; Mycoplasmas; Halophiles; Orientia; Mycobacterium leprae; genome size

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